MAP1 Antikörper (Center)

Produktnummer ABIN1887547

Produktdetails anti-MAP1 Antikörper

Target: MAP1 (Mannosidase Processing 1 (MAP1))

Bindungsspezifität: Center

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MAP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: 15 amino acid peptide from near the center of human MAP-1.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.

Handhabung: Avoid freezing and thawing repeatly.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 4 °C for short term use.Store at -20 °C for long term preservation.

Details zu MAP1

Target: MAP1 (Mannosidase Processing 1 (MAP1))

Andere Bezeichnung: MAP1 (MAP1 Produkte)

Synonyme: Map-1 antikoerper, Map1 antikoerper, mannosidase processing 1 antikoerper, Blood pressure QTL 196 antikoerper, Map1 antikoerper, Bp196 antikoerper

Hintergrund: Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells.Disruption of this process has been implicated in a variety of diseases such as cancer.Members of the Bcl-2 family are known to be critical regulators of this process.These proteins are characterized by the presence of several conserved motifs termed Bcl-2 homology (BH) domains.A related protein termed MAP-1 has recently been identified.This protein contains a BH3-like domain and induces caspase-dependent apoptosis in mammalian cells when overexpressed.It forms homodimers and associates with Bcl-2 family members such as Bax, Bcl-2, and Bcl-XL in vitro and in vivo.It has been suggested that MAP-1 associates with the tumor suppressor RASSF1A following death receptor activation, allowing a conformational change in Bax that leads to cellular apoptosis.

NCBI Accession: NP_071434

Pathways: Positive Regulation of Endopeptidase Activity