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FLT4 Antikörper (AA 1-439)

FLT4 Reaktivität: Human WB, FACS, IHC (p) Wirt: Maus Monoclonal 818CT12-1-1 unconjugated
Produktnummer ABIN1882290
  • Target Alle FLT4 Antikörper anzeigen
    FLT4 (Fms-Related Tyrosine Kinase 4 (FLT4))
    Bindungsspezifität
    • 16
    • 13
    • 6
    • 5
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-439
    Reaktivität
    • 76
    • 48
    • 16
    • 12
    Human
    Wirt
    • 67
    • 24
    • 5
    • 2
    Maus
    Klonalität
    • 68
    • 30
    Monoklonal
    Konjugat
    • 54
    • 8
    • 7
    • 5
    • 5
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser FLT4 Antikörper ist unkonjugiert
    Applikation
    • 52
    • 40
    • 36
    • 28
    • 14
    • 13
    • 13
    • 9
    • 8
    • 8
    • 5
    • 5
    • 3
    • 1
    • 1
    Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Aufreinigung
    This antibody is purified through a protein G column, followed by dialysis against PBS.
    Immunogen
    Purified His-tagged VEGFR3 protein was used to produced this monoclonal antibody.
    Klon
    818CT12-1-1
    Isotyp
    IgG2a
  • Applikationshinweise
    WB: 1:2000. IHC-P: 1:25. IHC-P: 1:25. IHC-P: 1:25. FC: 1:25
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Haltbarkeit
    6 months
  • Dai, Liu, Liu, Zhang, Wang, Jin, Qian, Wang, Zhao, Wu, Xiong, Chang, Sun, Yang, Hoffman, Liu: "Anti-metastatic Efficacy of Traditional Chinese Medicine (TCM) Ginsenoside Conjugated to a VEFGR-3 Antibody on Human Gastric Cancer in an Orthotopic Mouse Model." in: Anticancer research, Vol. 37, Issue 3, pp. 979-986, (2017) (PubMed).

    Irrthum, Karkkainen, Devriendt, Alitalo, Vikkula: "Congenital hereditary lymphedema caused by a mutation that inactivates VEGFR3 tyrosine kinase." in: American journal of human genetics, Vol. 67, Issue 2, pp. 295-301, (2000) (PubMed).

    Galland, Karamysheva, Pebusque, Borg, Rottapel, Dubreuil, Rosnet, Birnbaum: "The FLT4 gene encodes a transmembrane tyrosine kinase related to the vascular endothelial growth factor receptor." in: Oncogene, Vol. 8, Issue 5, pp. 1233-40, (1993) (PubMed).

    Pajusola, Aprelikova, Korhonen, Kaipainen, Pertovaara, Alitalo, Alitalo: "FLT4 receptor tyrosine kinase contains seven immunoglobulin-like loops and is expressed in multiple human tissues and cell lines." in: Cancer research, Vol. 52, Issue 20, pp. 5738-43, (1992) (PubMed).

    Galland, Karamysheva, Mattei, Rosnet, Marchetto, Birnbaum: "Chromosomal localization of FLT4, a novel receptor-type tyrosine kinase gene." in: Genomics, Vol. 13, Issue 2, pp. 475-8, (1992) (PubMed).

  • Target
    FLT4 (Fms-Related Tyrosine Kinase 4 (FLT4))
    Andere Bezeichnung
    VEGFR3 (FLT4 Produkte)
    Synonyme
    FLT41 antikoerper, LMPH1A antikoerper, PCL antikoerper, VEGFR3 antikoerper, AI323512 antikoerper, Chy antikoerper, Flt-4 antikoerper, VEGFR-3 antikoerper, Vegfr3 antikoerper, cb1059 antikoerper, fms related tyrosine kinase 4 antikoerper, FMS-like tyrosine kinase 4 antikoerper, fms-related tyrosine kinase 4 antikoerper, FLT4 antikoerper, Flt4 antikoerper, flt4 antikoerper
    Hintergrund
    Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting. Signaling by activated FLT4 leads to enhanced production of VEGFC, and to a lesser degree VEGFA, thereby creating a positive feedback loop that enhances FLT4 signaling. Modulates KDR signaling by forming heterodimers. The secreted isoform 3 may function as a decoy receptor for VEGFC and/or VEGFD and play an important role as a negative regulator of VEGFC-mediated lymphangiogenesis and angiogenesis. Binding of vascular growth factors to isoform 1 or isoform 2 leads to the activation of several signaling cascades, isoform 2 seems to be less efficient in signal transduction, because it has a truncated C-terminus and therefore lacks several phosphorylation sites. Mediates activation of the MAPK1/ERK2, MAPK3/ERK1 signaling pathway, of MAPK8 and the JUN signaling pathway, and of the AKT1 signaling pathway. Phosphorylates SHC1. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Promotes phosphorylation of MAPK8 at 'Thr-183' and 'Tyr-185', and of AKT1 at 'Ser-473'.
    Molekulargewicht
    152757
    NCBI Accession
    NP_002011, NP_891555
    UniProt
    P35916
    Pathways
    RTK Signalweg, Signaling Events mediated by VEGFR1 and VEGFR2, VEGF Signaling
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