CYP2C9 Antikörper (N-Term)

Produktnummer ABIN1882233

Produktdetails anti-CYP2C9 Antikörper

Target: CYP2C9 (Cytochrome P450, Family 2, Subfamily C, Polypeptide 9 (CYP2C9))

Bindungsspezifität: AA 82-110, N-Term

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CYP2C9 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.

Immunogen: This CYP2C9 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 82-110 amino acids from the N-terminal region of human CYP2C9.

Klon: 682CT5-6-2

Isotyp: IgM

Anwendungsinformationen

Applikationshinweise: WB: 1:100~1600

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Mouse monoclonal antibody supplied in crude ascites with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-CYP2C9 Antikörper (ABIN1882233)

Yang, Cui, Hasi, Jia, Gong, Su: "Genetic polymorphisms of cytochrome P450 enzymes 2C9 and 2C19 in a healthy Mongolian population in China." in: Genetics and molecular research : GMR, Vol. 9, Issue 3, pp. 1844-51, (2010) (PubMed).

Ikejiri, Wada, Sakamoto, Ito, Nishioka, Nakatani, Tsuji, Yamada, Nakamura, Ito, Nobori: "The association of protein S Tokushima-K196E with a risk of deep vein thrombosis." in: International journal of hematology, Vol. 92, Issue 2, pp. 302-5, (2010) (PubMed).

Schelleman, Brensinger, Chen, Finkelman, Rieder, Kimmel: "New genetic variant that might improve warfarin dose prediction in African Americans." in: British journal of clinical pharmacology, Vol. 70, Issue 3, pp. 393-9, (2010) (PubMed).

Details zu CYP2C9

Target: CYP2C9 (Cytochrome P450, Family 2, Subfamily C, Polypeptide 9 (CYP2C9))

Andere Bezeichnung: CYP2C9 (CYP2C9 Produkte)

Synonyme: CPC9 antikoerper, CYP2C antikoerper, CYP2C10 antikoerper, CYPIIC9 antikoerper, P450IIC9 antikoerper, cytochrome P450 family 2 subfamily C member 9 antikoerper, CYP2C9 antikoerper

Hintergrund: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by rifampin. The enzyme is known to metabolize many xenobiotics, including phenytoin, tolbutamide, ibuprofen and S-warfarin. Studies identifying individuals who are poor metabolizers of phenytoin and tolbutamide suggest that this gene is polymorphic. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24.

Molekulargewicht: 55628

NCBI Accession: NP_000762

UniProt: P11712