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USP2 Antikörper (AA 245-275)

USP2 Reaktivität: Human Wirt: Kaninchen Polyclonal RB4416 unconjugated
Produktnummer ABIN1882149
  • Target Alle USP2 Antikörper anzeigen
    USP2 (Ubiquitin Specific Peptidase 2 (USP2))
    Bindungsspezifität
    • 16
    • 10
    • 9
    • 8
    • 7
    • 6
    • 6
    • 6
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    AA 245-275
    Reaktivität
    • 72
    • 10
    • 9
    • 7
    • 6
    • 6
    • 6
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 69
    • 4
    Kaninchen
    Klonalität
    • 71
    • 2
    Polyklonal
    Konjugat
    • 34
    • 8
    • 7
    • 7
    • 5
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser USP2 Antikörper ist unkonjugiert
    Applikation
    Bitte anfragen
    Homologie
    B, M, Rat
    Aufreinigung
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogen
    This USP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 245-275 amino acids from human USP2.
    Klon
    RB4416
    Isotyp
    Ig Fraction
    Top Product
    Discover our top product USP2 Primärantikörper
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Haltbarkeit
    6 months
  • Tong, Buelow, Guha, Rausch, Yin: "USP2a protein deubiquitinates and stabilizes the circadian protein CRY1 in response to inflammatory signals." in: The Journal of biological chemistry, Vol. 287, Issue 30, pp. 25280-91, (2012) (PubMed).

    Haimerl, Erhardt, Sass, Tiegs: "Down-regulation of the de-ubiquitinating enzyme ubiquitin-specific protease 2 contributes to tumor necrosis factor-alpha-induced hepatocyte survival." in: The Journal of biological chemistry, Vol. 284, Issue 1, pp. 495-504, (2008) (PubMed).

    Strausberg, Feingold, Grouse, Derge, Klausner, Collins, Wagner, Shenmen, Schuler, Altschul, Zeeberg, Buetow, Schaefer, Bhat, Hopkins, Jordan, Moore, Max, Wang, Hsieh, Diatchenko, Marusina, Farmer et al.: "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ..." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 26, pp. 16899-903, (2002) (PubMed).

  • Target
    USP2 (Ubiquitin Specific Peptidase 2 (USP2))
    Andere Bezeichnung
    USP2 (USP2 Produkte)
    Synonyme
    UBP41 antikoerper, USP9 antikoerper, B930035K21Rik antikoerper, Ubp41 antikoerper, UBP-t antikoerper, UBP46 antikoerper, ubp52 antikoerper, ubp66 antikoerper, zgc:92134 antikoerper, ubiquitin specific peptidase 2 antikoerper, ubiquitin specific peptidase 2a antikoerper, USP2 antikoerper, Usp2 antikoerper, usp2a antikoerper
    Hintergrund
    Modification of target proteins by ubiquitin participates in a wide array of biological functions. Proteins destined for degradation or processing via the 26 S proteasome are coupled to multiple copies of ubiquitin. However, attachment of ubiquitin or ubiquitin-related molecules may also result in changes in subcellular distribution or modification of protein activity. An additional level of ubiquitin regulation, deubiquitination, is catalyzed by proteases called deubiquitinating enzymes, which fall into four distinct families. Ubiquitin C-terminal hydrolases, ubiquitin-specific processing proteases (USPs),1 OTU-domain ubiquitin-aldehyde-binding proteins, and Jab1/Pad1/MPN-domain-containing metallo-enzymes. Among these four families, USPs represent the most widespread and represented deubiquitinating enzymes across evolution. USPs tend to release ubiquitin from a conjugated protein. They display similar catalytic domains containing conserved Cys and His boxes but divergent N-terminal and occasionally C-terminal extensions, which are thought to function in substrate recognition, subcellular localization, and protein-protein interactions.
    Molekulargewicht
    68072
    NCBI Accession
    NP_001230688, NP_004196, NP_741994
    UniProt
    O75604
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