SHP1 Antikörper (AA 247-277)

Produktnummer ABIN1882123

Produktdetails anti-SHP1 Antikörper

Target: SHP1 (PTPN6) (Protein-tyrosine Phosphatase 1C (PTPN6))

Bindungsspezifität: AA 247-277

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SHP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This PTPN6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 247-277 amino acids from the Central region of human PTPN6.

Klon: RB17225

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: IF: 1:100. WB: 1:1000. WB: 1:1000. IHC-P: 1:10~50

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-SHP1 Antikörper (ABIN1882123)

Korporaal, Koekman, Verhoef, van der Wal, Bezemer, Van Eck, Akkerman: "Downregulation of platelet responsiveness upon contact with LDL by the protein-tyrosine phosphatases SHP-1 and SHP-2." in: Arteriosclerosis, thrombosis, and vascular biology, Vol. 29, Issue 3, pp. 372-9, (2009) (PubMed).

Cho, Oh, Zhu: "Tyrosine phosphatase SHP-1 in oxidative stress and development of allergic airway inflammation." in: American journal of respiratory cell and molecular biology, Vol. 39, Issue 4, pp. 412-9, (2008) (PubMed).

Details zu SHP1

Target: SHP1 (PTPN6) (Protein-tyrosine Phosphatase 1C (PTPN6))

Andere Bezeichnung: PTPN6 (PTPN6 Produkte)

Synonyme: HCPH antikoerper, HPTP1C antikoerper, PTP-1C antikoerper, SH-PTP1 antikoerper, SHP-1 antikoerper, SHP-1L antikoerper, SHP1 antikoerper, DRPLA antikoerper, Hcph antikoerper, Ptp1C antikoerper, me antikoerper, motheaten antikoerper, Ptph6 antikoerper, Shp-1 antikoerper, fj22f05 antikoerper, wu:fj22f05 antikoerper, zgc:55501 antikoerper, ptpn6 antikoerper, protein tyrosine phosphatase, non-receptor type 6 antikoerper, protein tyrosine phosphatase, non-receptor type 6 L homeolog antikoerper, PTPN6 antikoerper, Ptpn6 antikoerper, ptpn6 antikoerper, ptpn6.L antikoerper

Hintergrund: PTPN6 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling.

Molekulargewicht: 67561

NCBI Accession: NP_002822, NP_536858, NP_536859

UniProt: P29350

Pathways: JAK-STAT Signalweg, T-Zell Rezeptor Signalweg, TLR Signalweg, Nuclear Receptor Transcription Pathway, Positive Regulation of Peptide Hormone Secretion, Steroid Hormone Mediated Signaling Pathway, Response to Growth Hormone Stimulus, Regulation of Leukocyte Mediated Immunity, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, BCR Signaling