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PINK1 Antikörper (AA 237-266)

PINK1 Reaktivität: Human WB Wirt: Kaninchen Polyclonal RB7383 unconjugated
Produktnummer ABIN1882117
  • Target Alle PINK1 Antikörper anzeigen
    PINK1 (PTEN Induced Putative Kinase 1 (PINK1))
    Bindungsspezifität
    • 21
    • 12
    • 12
    • 7
    • 7
    • 6
    • 6
    • 6
    • 5
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 237-266
    Reaktivität
    • 90
    • 50
    • 24
    • 2
    • 2
    • 1
    • 1
    • 1
    Human
    Wirt
    • 71
    • 33
    • 1
    Kaninchen
    Klonalität
    • 75
    • 32
    Polyklonal
    Konjugat
    • 49
    • 10
    • 9
    • 7
    • 6
    • 6
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Dieser PINK1 Antikörper ist unkonjugiert
    Applikation
    • 83
    • 53
    • 48
    • 18
    • 16
    • 6
    • 5
    • 4
    • 3
    • 1
    • 1
    Western Blotting (WB)
    Aufreinigung
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogen
    This PINK1 (PARK6) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 237-266 amino acids from the Central region of human PINK1 (PARK6).
    Klon
    RB7383
    Isotyp
    Ig Fraction
    Top Product
    Discover our top product PINK1 Primärantikörper
  • Applikationshinweise
    WB: 1:1000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Haltbarkeit
    6 months
  • Mannam, Shinn, Srivastava, Neamu, Walker, Bohanon, Merkel, Kang, Dela Cruz, Ahasic, Pisani, Trentalange, West, Shadel, Elias, Lee: "MKK3 regulates mitochondrial biogenesis and mitophagy in sepsis-induced lung injury." in: American journal of physiology. Lung cellular and molecular physiology, Vol. 306, Issue 7, pp. L604-19, (2014) (PubMed).

    Geisler, Holmström, Skujat, Fiesel, Rothfuss, Kahle, Springer: "PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1." in: Nature cell biology, Vol. 12, Issue 2, pp. 119-31, (2010) (PubMed).

    Rogaeva, Johnson, Lang, Gulick, Gwinn-Hardy, Kawarai, Sato, Morgan, Werner, Nussbaum, Petit, Okun, McInerney, Mandel, Groen, Fernandez, Postuma, Foote: "Analysis of the PINK1 gene in a large cohort of cases with Parkinson disease." in: Archives of neurology, Vol. 61, Issue 12, pp. 1898-904, (2004) (PubMed).

    Hatano, Li, Sato, Asakawa, Yamamura, Tomiyama, Yoshino, Asahina, Kobayashi, Hassin-Baer, Lu, Ng, Rosales, Shimizu, Toda, Mizuno, Hattori: "Novel PINK1 mutations in early-onset parkinsonism." in: Annals of neurology, Vol. 56, Issue 3, pp. 424-7, (2004) (PubMed).

  • Target
    PINK1 (PTEN Induced Putative Kinase 1 (PINK1))
    Andere Bezeichnung
    PINK1 (PARK6) (PINK1 Produkte)
    Synonyme
    BEST:GH23468 antikoerper, CG4523 antikoerper, Dmel\\CG4523 antikoerper, PINK antikoerper, PINK1 antikoerper, dPINK1 antikoerper, dPink1 antikoerper, pink1 antikoerper, wu:fc39e12 antikoerper, zgc:101729 antikoerper, BRPK antikoerper, PARK6 antikoerper, 1190006F07Rik antikoerper, AU042772 antikoerper, AW557854 antikoerper, mFLJ00387 antikoerper, PTEN-induced putative kinase 1 antikoerper, PTEN induced putative kinase 1 antikoerper, Pink1 antikoerper, PINK1 antikoerper, pink1 antikoerper
    Hintergrund
    Parkinson is the second most common neurodegenerative disease after Alzheimers. About 1 percent of people over the age of 65 and 3 percent of people over the age of 75 are affected by the disease. The mutation is the most common cause of Parkinson disease identified to date. Defects in PINK1 are the cause of autosomal recessive early-onset Parkinson's disease 6 (PARK6). Six novel pathogenic PINK1 mutations suggest that PINK1 may be the second most common causative gene next to parkin in parkinsonism with the recessive mode of inheritance. Strong evidence indicates that, although important in mendelian forms of Parkinson's disease (PD), PINK1 does not influence the cause of sporadic nonmendelian forms of PD.
    Molekulargewicht
    62769
    NCBI Accession
    NP_115785
    UniProt
    Q9BXM7
    Pathways
    Autophagie
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