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Neuregulin 3 Antikörper (AA 688-717)

NRG3 Reaktivität: Human WB, IHC (p) Wirt: Kaninchen Polyclonal RB2201 unconjugated
Produktnummer ABIN1881587
  • Target Alle Neuregulin 3 (NRG3) Antikörper anzeigen
    Neuregulin 3 (NRG3)
    Bindungsspezifität
    • 15
    • 8
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 688-717
    Reaktivität
    • 26
    • 20
    • 8
    • 2
    • 2
    • 1
    • 1
    • 1
    Human
    Wirt
    • 40
    • 1
    Kaninchen
    Klonalität
    • 39
    • 2
    Polyklonal
    Konjugat
    • 15
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser Neuregulin 3 Antikörper ist unkonjugiert
    Applikation
    • 29
    • 14
    • 13
    • 13
    • 11
    • 9
    • 3
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Aufreinigung
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This NRG3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 688-717 amino acids of human NRG3.
    Klon
    RB2201
    Isotyp
    IgG
    Top Product
    Discover our top product NRG3 Primärantikörper
  • Applikationshinweise
    WB: 1:1000. IHC-P: 1:10~50
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Haltbarkeit
    6 months
  • Wansbury, Panchal, James, Parry, Ashworth, Howard: "Dynamic expression of Erbb pathway members during early mammary gland morphogenesis." in: The Journal of investigative dermatology, Vol. 128, Issue 4, pp. 1009-21, (2008) (PubMed).

    Zhang, Sliwkowski, Mark, Frantz, Akita, Sun, Hillan, Crowley, Brush, Godowski: "Neuregulin-3 (NRG3): a novel neural tissue-enriched protein that binds and activates ErbB4." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 18, pp. 9562-7, (1997) (PubMed).

  • Target
    Neuregulin 3 (NRG3)
    Andere Bezeichnung
    NRG3 (NRG3 Produkte)
    Synonyme
    NRG3 antikoerper, HRG3 antikoerper, pro-NRG3 antikoerper, ska antikoerper, RGD1559678 antikoerper, neuregulin 3 antikoerper, pro-neuregulin-3, membrane-bound isoform antikoerper, NRG3 antikoerper, nrg3 antikoerper, LOC100478170 antikoerper, Nrg3 antikoerper
    Hintergrund
    NRG3, which belongs to the neuregulin family, is a direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. NRG3 does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. The protein exists as an type I membrane protein and as a proteolytically released soluble growth factor form. The membrane-bound form does not appear to be active. NRG3 is highly expressed in most regions of the brain with the exception of corpus callosum, and is expressed at lower level in testis. It is not detected in heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, ovary, small intestine, colon and peripheral blood leukocytes. The NRG3 cytoplasmic domain may be involved in the regulation of trafficking and proteolytic processing. Regulation of the proteolytic processing may involve initial intracellular domain dimerization.
    Molekulargewicht
    77901
    NCBI Accession
    NP_001010848, NP_001159445
    UniProt
    P56975
    Pathways
    RTK Signalweg
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