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ErbB2/Her2 Antikörper (pTyr1112)

ErbB2/Her2 Reaktivität: Human WB, DB Wirt: Kaninchen Polyclonal RB40063 unconjugated
Produktnummer ABIN1881304
  • Target Alle ErbB2/Her2 Antikörper anzeigen
    ErbB2/Her2 (Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))
    Bindungsspezifität
    • 32
    • 29
    • 27
    • 26
    • 25
    • 23
    • 23
    • 20
    • 18
    • 16
    • 15
    • 13
    • 10
    • 10
    • 9
    • 9
    • 9
    • 9
    • 8
    • 8
    • 8
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 6
    • 6
    • 5
    • 5
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    pTyr1112
    Reaktivität
    • 517
    • 187
    • 164
    • 34
    • 10
    • 7
    • 5
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 408
    • 156
    • 11
    • 5
    • 3
    • 3
    Kaninchen
    Klonalität
    • 411
    • 172
    • 2
    Polyklonal
    Konjugat
    • 268
    • 46
    • 38
    • 29
    • 25
    • 24
    • 17
    • 17
    • 16
    • 16
    • 15
    • 15
    • 8
    • 8
    • 8
    • 8
    • 8
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    Dieser ErbB2/Her2 Antikörper ist unkonjugiert
    Applikation
    • 299
    • 229
    • 138
    • 104
    • 95
    • 93
    • 92
    • 80
    • 67
    • 53
    • 29
    • 21
    • 12
    • 9
    • 8
    • 7
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Dot Blot (DB)
    Aufreinigung
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This ErbB2 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y1112 of human ErbB2.
    Klon
    RB40063
    Isotyp
    Ig Fraction
    Top Product
    Discover our top product ErbB2/Her2 Primärantikörper
  • Applikationshinweise
    WB: 1:2000. DB: 1:500
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Haltbarkeit
    6 months
  • Mándoky, Géczi, Bodrogi, Tóth, Csuka, Kásler, Bak: "Clinical relevance of HER-2/neu expression in germ-cell testicular tumors." in: Anticancer research, Vol. 24, Issue 4, pp. 2219-24, (2004) (PubMed).

    Contreras, Cobos, Lox: "Is the circulating urokinase plasminogen activator upregulated by the circulating p105 fraction of the HER-2/neu proto-oncogene in patients with cervical cancer?" in: Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis, Vol. 10, Issue 3, pp. 271-6, (2004) (PubMed).

    Stephens, Hunter, Bignell, Edkins, Davies, Teague, Stevens, OMeara, Smith, Parker, Barthorpe, Blow, Brackenbury, Butler, Clarke, Cole, Dicks, Dike, Drozd, Edwards, Forbes, Foster, Gray, Greenman et al.: "Lung cancer: intragenic ERBB2 kinase mutations in tumours. ..." in: Nature, Vol. 431, Issue 7008, pp. 525-6, (2004) (PubMed).

    Wang, Lien, Xia, Chen, Lo, Wang, Ali-Seyed, Lee, Bartholomeusz, Ou-Yang, Giri, Hung: "Binding at and transactivation of the COX-2 promoter by nuclear tyrosine kinase receptor ErbB-2." in: Cancer cell, Vol. 6, Issue 3, pp. 251-61, (2004) (PubMed).

    Menendez, Vellon, Mehmi, Oza, Ropero, Colomer, Lupu: "Inhibition of fatty acid synthase (FAS) suppresses HER2/neu (erbB-2) oncogene overexpression in cancer cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 29, pp. 10715-20, (2004) (PubMed).

  • Target
    ErbB2/Her2 (Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))
    Andere Bezeichnung
    ERBB2 (ErbB2/Her2 Produkte)
    Synonyme
    CD340 antikoerper, HER-2 antikoerper, HER-2/neu antikoerper, HER2 antikoerper, MLN 19 antikoerper, NEU antikoerper, NGL antikoerper, TKR1 antikoerper, Erbb-2 antikoerper, Neu antikoerper, c-erbB2 antikoerper, c-neu antikoerper, mKIAA3023 antikoerper, wu:fv70f10 antikoerper, zgc:63601 antikoerper, erb2 antikoerper, erb-b2 receptor tyrosine kinase 2 antikoerper, ERBB2 antikoerper, Erbb2 antikoerper, erbb2 antikoerper
    Hintergrund
    ErbB2 is a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors.
    Molekulargewicht
    137910
    NCBI Accession
    NP_001005862, NP_004439
    UniProt
    P04626
    Pathways
    RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Skeletal Muscle Fiber Development
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