CTNNB1 Antikörper (C-Term)

Produktnummer ABIN1881237

Produktdetails anti-CTNNB1 Antikörper

Target: CTNNB1 (Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1))

Bindungsspezifität: AA 723-751, C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CTNNB1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Homologie: B, M, Rat

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This CTNNB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 723-751 amino acids from the C-terminal region of human CTNNB1.

Klon: RB41158

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-CTNNB1 Antikörper (ABIN1881237)

Huang, Wang, Guo, Jia, Lin, Li, Wang, Chen: "Approaching the intrinsic electron field-emission of a graphene film consisting of quasi-freestanding graphene strips." in: Small (Weinheim an der Bergstrasse, Germany), Vol. 7, Issue 4, pp. 450-4, (2011) (PubMed).

Huang, Zhou, Saberwal, Konieczna, Horvath, Katsoulidis, Platanias, Eklund: "Interferon consensus sequence binding protein (ICSBP) decreases beta-catenin activity in myeloid cells by repressing GAS2 transcription." in: Molecular and cellular biology, Vol. 30, Issue 19, pp. 4575-94, (2010) (PubMed).

Chairoungdua, Smith, Pochard, Hull, Caplan: "Exosome release of ?-catenin: a novel mechanism that antagonizes Wnt signaling." in: The Journal of cell biology, Vol. 190, Issue 6, pp. 1079-91, (2010) (PubMed).

Mirza, Sun, Zhao, Potula, Frey, Vogel, Malik, Zhao: "FoxM1 regulates re-annealing of endothelial adherens junctions through transcriptional control of beta-catenin expression." in: The Journal of experimental medicine, Vol. 207, Issue 8, pp. 1675-85, (2010) (PubMed).

Teng, Wang, Wang, Wang: "[Effect of siRNA-mediated beta-catenin gene on Wnt signal pathway in lung adenocarcinoma A549 cell]." in: Zhonghua yi xue za zhi, Vol. 90, Issue 14, pp. 988-92, (2010) (PubMed).

Details zu CTNNB1

Target: CTNNB1 (Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1))

Andere Bezeichnung: CTNNB1 (CTNNB1 Produkte)

Synonyme: Jup antikoerper, LOC100217813 antikoerper, CTNNB1 antikoerper, CTNNB antikoerper, Bfc antikoerper, Catnb antikoerper, Mesc antikoerper, ctnnb antikoerper, id:ibd2058 antikoerper, wu:fb73e10 antikoerper, wu:fi81c06 antikoerper, wu:fk25h01 antikoerper, ctnnb1 antikoerper, CHBCAT antikoerper, MRD19 antikoerper, armadillo antikoerper, beta-catenin antikoerper, catenin beta 1 antikoerper, catenin (cadherin associated protein), beta 1 antikoerper, catenin (cadherin-associated protein), beta 1 antikoerper, catenin beta 1 S homeolog antikoerper, catenin beta 1 L homeolog antikoerper, CTNNB1 antikoerper, Ctnnb1 antikoerper, ctnnb1 antikoerper, ctnnb1.S antikoerper, ctnnb1.L antikoerper

Hintergrund: The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for this gene.

Molekulargewicht: 85497

NCBI Accession: NP_001091679, NP_001091680, NP_001895

UniProt: P35222

Pathways: WNT Signalweg, Intracellular Steroid Hormone Receptor Signaling Pathway, Peptide Hormone Metabolism, Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Tube Formation, Maintenance of Protein Location, Signaling Events mediated by VEGFR1 and VEGFR2