APOBEC3A Antikörper (N-Term)

Produktnummer ABIN1881066

Produktdetails anti-APOBEC3A Antikörper

Target: APOBEC3A (Apolipoprotein B mRNA Editing Enzyme, Catalytic Polypeptide-Like 3A (APOBEC3A))

Bindungsspezifität: AA 20-49, N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser APOBEC3A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This APOBEC3A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 20-49 amino acids from the N-terminal region of human APOBEC3A.

Klon: RB42401

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-APOBEC3A Antikörper (ABIN1881066)

Thielen, McNevin, McElrath, Hunt, Klein, Lingappa: "Innate immune signaling induces high levels of TC-specific deaminase activity in primary monocyte-derived cells through expression of APOBEC3A isoforms." in: The Journal of biological chemistry, Vol. 285, Issue 36, pp. 27753-66, (2010) (PubMed).

Berger, Münk, Schweizer, Cichutek, Schüle, Flory: "Interaction of Vpx and apolipoprotein B mRNA-editing catalytic polypeptide 3 family member A (APOBEC3A) correlates with efficient lentivirus infection of monocytes." in: The Journal of biological chemistry, Vol. 285, Issue 16, pp. 12248-54, (2010) (PubMed).

Stenglein, Burns, Li, Lengyel, Harris: "APOBEC3 proteins mediate the clearance of foreign DNA from human cells." in: Nature structural & molecular biology, Vol. 17, Issue 2, pp. 222-9, (2010) (PubMed).

Abe, Ochi, Maekawa, Hatakeyama, Tsuge, Kitamura, Kimura, Miki, Mitsui, Hiraga, Imamura, Fujimoto, Takahashi, Nakamura, Kumada, Chayama: "Effects of structural variations of APOBEC3A and APOBEC3B genes in chronic hepatitis B virus infection." in: Hepatology research : the official journal of the Japan Society of Hepatology, Vol. 39, Issue 12, pp. 1159-68, (2009) (PubMed).

Prochnow, Bransteitter, Chen: "APOBEC deaminases-mutases with defensive roles for immunity." in: Science in China. Series C, Life sciences / Chinese Academy of Sciences, Vol. 52, Issue 10, pp. 893-902, (2009) (PubMed).

Details zu APOBEC3A

Target: APOBEC3A (Apolipoprotein B mRNA Editing Enzyme, Catalytic Polypeptide-Like 3A (APOBEC3A))

Andere Bezeichnung: APOBEC3A (APOBEC3A Produkte)

Synonyme: A3A antikoerper, ARP3 antikoerper, PHRBN antikoerper, bK150C2.1 antikoerper, APOBEC3A antikoerper, APOBEC3Z1 antikoerper, apolipoprotein B mRNA editing enzyme catalytic subunit 3A antikoerper, apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A antikoerper, apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3Z1 antikoerper, similar to ARP10 protein antikoerper, APOBEC3A antikoerper, APOBEC3Z1 antikoerper

Hintergrund: This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. The protein encoded by this gene lacks the zinc binding activity of other family members. The protein plays a role in immunity, by restricting transmission of foreign DNA such as viruses. One mechanism of foreign DNA restriction is deamination of foreign double-stranded DNA cytidines to uridines, which leads to DNA degradation. However, other mechanisms are also thought to be involved, as anti-viral effect is not dependent on deaminase activity. One allele of this gene results from the deletion of approximately 29.5 kb of sequence between this gene, APOBEC3A, and the adjacent gene APOBEC3B. The breakpoints of the deletion are within the two genes, so the deletion allele is predicted to have the promoter and coding region of APOBEC3A, but the 3' UTR of APOBEC3B.

Molekulargewicht: 23012

NCBI Accession: NP_001180218, NP_663745

UniProt: P31941