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Macrophage Mannose Receptor 1 Antikörper

MRC1 Reaktivität: Maus FACS, IP, IHC (fro), IF Wirt: Ratte Monoclonal MR5D3 unconjugated
Produktnummer ABIN181886
  • Target Alle Macrophage Mannose Receptor 1 (MRC1) Antikörper anzeigen
    Macrophage Mannose Receptor 1 (MRC1) (Mannose Receptor, C Type 1 (MRC1))
    Reaktivität
    • 72
    • 41
    • 23
    • 16
    • 1
    • 1
    Maus
    Wirt
    • 43
    • 31
    • 15
    Ratte
    Klonalität
    • 44
    • 41
    Monoklonal
    Konjugat
    • 35
    • 8
    • 8
    • 7
    • 6
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser Macrophage Mannose Receptor 1 Antikörper ist unkonjugiert
    Applikation
    • 53
    • 51
    • 23
    • 15
    • 13
    • 11
    • 9
    • 8
    • 6
    • 5
    • 5
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF)
    Spezifität
    This antibody recognises the Mannose Receptor, a 175 kDa type 1 membrane protein that is also known as CD206. Clone MR5D3 has been reported to be non-inhibitory for the binding of the mannose receptor to carbohydrate ligands.
    Aufreinigung
    Affinity Chromatography on Protein G
    Immunogen
    Chimaeric CRD4-7-Fc protein. Remarks: Spleen cells from immunised Fischer rats were fused with cells of the Y3 myeloma cell line.
    Klon
    MR5D3
    Isotyp
    IgG2a
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  • Applikationshinweise
    Western Blot. Immunoprecipitation. Immunohistochemistry on frozen sections. Flow Cytometry: 1/10 - 1/20, Use 10 μL of the suggested working dilution to label 10^6 cell in 100 μL, CD206 is expressed weakly at the cell surface. Staining may be increased following membrane permeabilisation.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1.0 mg/mL
    Buffer
    PBS, pH 7.4 containing 0.09 % Sodium Azide as preservative
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target
    Macrophage Mannose Receptor 1 (MRC1) (Mannose Receptor, C Type 1 (MRC1))
    Andere Bezeichnung
    CD206 / MRC1 (MRC1 Produkte)
    Synonyme
    CD206 antikoerper, CLEC13D antikoerper, CLEC13DL antikoerper, MMR antikoerper, MRC1L1 antikoerper, bA541I19.1 antikoerper, AW259686 antikoerper, MR antikoerper, mrc1 antikoerper, MGC86525 antikoerper, MRC1 antikoerper, MRC1L-A antikoerper, mannose receptor C-type 1 antikoerper, mannose receptor, C type 1 antikoerper, mannose receptor C-type 1 L homeolog antikoerper, mediator of replication checkpoint 1 antikoerper, MRC1 antikoerper, Mrc1 antikoerper, mrc1.L antikoerper, mrc1 antikoerper
    Hintergrund
    CD206, also known as macrophage mannose receptor type C (MMR or MRC1), is a type I membrane receptor protein. CD206 is a phagocytic and endocytic receptor that can recognize carbohydrate ligands in target molecules. The extracellular portion of the protein includes eight C-type carbohydrate recognition domains (CRD) which are clustered together to achieve higher affinity binding to saccharides. CD206 is found on macrophages and on endothelial cells of the liver and is the only known example of a C-type lectin that contains multiple C-type CRDs. CD206 mediates the endocytosis of glycoproteins by macrophages and binds high-mannose structures on the surface of potentially pathogenic viruses, fungi and bacteria enabling them to be neutralized by phagocytic engulfment. During inflammation, CD206 is crucial for rapid clearance of several mannose-bearing serum glycoproteins but does not regulate the initiation of inflammation. CD206 is primarily expressed in mature tissue macrophages and immature Dendritic cells, as well as hepatic and lymphatic endothelial cells, retinal pigmental epithelium (RPE) and mesangial cells.Synonyms: C-type lectin domain family 13 member D, C-type lectin domain family 13 member D-like, CLEC13D, CLEC13DL, MRC1L1, Macrophage mannose receptor, Macrophage mannose receptor 1-like protein 1
    Gen-ID
    17533
    NCBI Accession
    NP_032651
    UniProt
    Q61830
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