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ATF4 Antikörper (AA 25-327) (Alkaline Phosphatase (AP))

ATF4 Reaktivität: Human WB, IHC, ICC, IF Wirt: Maus Monoclonal S360A-24 Alkaline Phosphatase (AP)
Produktnummer ABIN1741062
  • Target Alle ATF4 Antikörper anzeigen
    ATF4 (Activating Transcription Factor 4 (Tax-Responsive Enhancer Element B67) (ATF4))
    Bindungsspezifität
    • 25
    • 19
    • 16
    • 10
    • 10
    • 8
    • 8
    • 7
    • 7
    • 6
    • 6
    • 6
    • 5
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 25-327
    Reaktivität
    • 157
    • 56
    • 49
    • 23
    • 16
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    Human
    Wirt
    • 138
    • 28
    • 1
    Maus
    Klonalität
    • 130
    • 37
    Monoklonal
    Konjugat
    • 78
    • 12
    • 9
    • 9
    • 7
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser ATF4 Antikörper ist konjugiert mit Alkaline Phosphatase (AP)
    Applikation
    • 130
    • 72
    • 41
    • 27
    • 26
    • 21
    • 19
    • 19
    • 13
    • 9
    • 6
    • 6
    • 3
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF)
    Spezifität
    Detects ~60 kDa. Does not cross-react with ATF5.
    Kreuzreaktivität
    Human, Ratte
    Aufreinigung
    Protein G Purified
    Immunogen
    Fusion protein amino acids 25-327 of human ATF4. 86% identical to rat, and 85% identical to mouse. <50% identity with ATF5.
    Klon
    S360A-24
    Isotyp
    IgG2a
    Top Product
    Discover our top product ATF4 Primärantikörper
  • Applikationshinweise
    • WB (1:1000)
    • optimal dilutions for assays should be determined by the user.
    Kommentare

    1 μg/ml of ABIN1741062 was sufficient for detection of ATF4 in 20 μg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    PBS pH 7.4, 50 % glycerol, 0.1 % sodium azide, Storage buffer may change when conjugated
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Conjugated antibodies should be stored at 4°C
  • Target
    ATF4 (Activating Transcription Factor 4 (Tax-Responsive Enhancer Element B67) (ATF4))
    Andere Bezeichnung
    ATF4 (ATF4 Produkte)
    Synonyme
    CREB-2 antikoerper, CREB2 antikoerper, TAXREB67 antikoerper, TXREB antikoerper, ATF4 antikoerper, atf-4 antikoerper, creb-2 antikoerper, creb2 antikoerper, taxreb67 antikoerper, txreb antikoerper, atf4 antikoerper, wu:fj01c08 antikoerper, wu:fk30b04 antikoerper, zgc:85951 antikoerper, sb:eu681 antikoerper, wu:fb08f07 antikoerper, zgc:171702 antikoerper, Atf-4 antikoerper, C/ATF antikoerper, ATF4-I antikoerper, atf4-a antikoerper, atf4-b antikoerper, atf4-ii antikoerper, activating transcription factor 4 antikoerper, activating transcription factor 4 L homeolog antikoerper, activating transcription factor 4a antikoerper, activating transcription factor 4b antikoerper, activating transcription factor 4 S homeolog antikoerper, ATF4 antikoerper, atf4 antikoerper, Atf4 antikoerper, atf4.L antikoerper, atf4a antikoerper, atf4b antikoerper, atf4.S antikoerper
    Hintergrund
    Cyclic AMP-dependent transcription factor ATF-4 (ATF4) is a basic leucine-zipper (bZip) transcription factor, which regulates amino acid metabolism, DNA damage repair, chromatin remodeling, and apoptosis in response to cellular and ER stress. ATF4 works with various proteins, such as C/EBP homology protein (CHOP), aspargine synthetase (ASNS), and cAMP response element (CRE) among others to mediate cellular stress. ATF4 also regulates glucose homeostasis by suppressing beta-cell proliferation and insulin production. Furthermore, ATF4 targets the histone demethylase JMJD3 to alter chromatin structure and enhance gene transcription in response to amino acid deprivation.
    Gen-ID
    468
    NCBI Accession
    NP_001666
    UniProt
    P18848
    Pathways
    Thyroid Hormone Synthesis, Myometrial Relaxation and Contraction, ER-Nucleus Signaling, Unfolded Protein Response
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