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PTPRF Antikörper (AA 1315-1607) (Atto 488)

PTPRF Reaktivität: Human WB, ICC, IF Wirt: Maus Monoclonal S165-38 Atto 488
Produktnummer ABIN1740983
  • Target Alle PTPRF Antikörper anzeigen
    PTPRF (Protein Tyrosine Phosphatase Receptor Type F (PTPRF))
    Bindungsspezifität
    • 20
    • 16
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1315-1607
    Reaktivität
    • 56
    • 5
    • 5
    • 3
    • 1
    Human
    Wirt
    • 28
    • 26
    • 3
    Maus
    Klonalität
    • 32
    • 25
    Monoklonal
    Konjugat
    • 20
    • 5
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser PTPRF Antikörper ist konjugiert mit Atto 488
    Applikation
    • 33
    • 20
    • 18
    • 14
    • 13
    • 13
    • 11
    • 5
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)
    Spezifität
    Detects ~85 kDa (full length protein is 210 kDa - smaller due to proteolysis into P-subunit containing transmembrane and intracellular domains.
    Kreuzreaktivität
    Human, Maus, Ratte
    Aufreinigung
    Protein G Purified
    Immunogen
    Fusion protein amino acids 1315-1607 (cytoplasmic C-terminus) of human LAR. 97% identical in both rat and mouse. >80% identity with PTPRD and PTPRS. >50% identity with PTPRM and PTPRK.
    Klon
    S165-38
    Isotyp
    IgG2a
    Top Product
    Discover our top product PTPRF Primärantikörper
  • Applikationshinweise
    • WB (1:1000)
    • optimal dilutions for assays should be determined by the user.
    Kommentare

    1 μg/ml of ABIN1740983 was sufficient for detection of LAR/PTPRF in 20 μg of rat brain lysate by colorimetric immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    PBS pH 7.4, 50 % glycerol, 0.1 % sodium azide, Storage buffer may change when conjugated
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C
    Informationen zur Lagerung
    Conjugated antibodies should be stored at 4°C
  • Target
    PTPRF (Protein Tyrosine Phosphatase Receptor Type F (PTPRF))
    Andere Bezeichnung
    LAR (PTPRF Produkte)
    Synonyme
    LAR antikoerper, AA591035 antikoerper, LARS antikoerper, RPTP-LAR antikoerper, LARFN5C antikoerper, zf-LAR antikoerper, protein tyrosine phosphatase, receptor type F antikoerper, protein tyrosine phosphatase, receptor type, F antikoerper, protein tyrosine phosphatase, receptor type, f, a antikoerper, PTPRF antikoerper, Ptprf antikoerper, ptprfa antikoerper
    Hintergrund
    PTPRF or leukocyte common antigen-related protein (LAR) is a widely expressed protein tyrosine phosphatase with an extracellular receptor region that resembles a cell adhesion molecule. PTPRF removes phosphate group from β-catenin, an event that may subsequently facilitate cell-cell adhesion and ensure the stability of the cadherin complex. This phosphatase has also been implicated in various cellular processes such as neurite growth, nerve regeneration, actin remodeling and regulation of insulin function (1,2,3,4). Anti-PTPRF (C-terminal) antibody is specific for the extracellular and cytoplasmic subunits of human PTPRF (approx. 210, 150 and 85 kDa). Detection of the PTPRF bands by immunoblotting is specifically inhibited by the immunizing peptide.
    Gen-ID
    5792
    UniProt
    P10586
    Pathways
    EGFR Signaling Pathway
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