Raptor Antikörper (AA 874-1009)

Produktnummer ABIN1724920

Produktdetails anti-Raptor Antikörper

Target: Raptor (RPTOR) (Regulatory Associated Protein of mTOR, Complex 1 (RPTOR))

Bindungsspezifität: AA 874-1009

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Raptor Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB)

Aufreinigung: purified

Immunogen: Purified recombinant fragment of human RPTOR (AA: 874-1009) expressed in E. coli.

Klon: 6G9C4

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: ELISA: 1:10000, WB: 1:500 - 1:2000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: 4°C, -20°C for long term storage

Referenzen für anti-Raptor Antikörper (ABIN1724920)

Vazquez-Martin, Cufí, Oliveras-Ferraros, Menendez: "Raptor, a positive regulatory subunit of mTOR complex 1, is a novel phosphoprotein of the rDNA transcription machinery in nucleoli and chromosomal nucleolus organizer regions (NORs)." in: Cell cycle (Georgetown, Tex.), Vol. 10, Issue 18, pp. 3140-52, (2011) (PubMed).

Sun, Southard, Witonsky, Kittler, Di Rienzo: "Allele-specific down-regulation of RPTOR expression induced by retinoids contributes to climate adaptations." in: PLoS genetics, Vol. 6, Issue 10, pp. e1001178, (2010) (PubMed).

Details zu Raptor

Target: Raptor (RPTOR) (Regulatory Associated Protein of mTOR, Complex 1 (RPTOR))

Andere Bezeichnung: RPTOR (RPTOR Produkte)

Synonyme: KOG1 antikoerper, Mip1 antikoerper, 4932417H02Rik antikoerper, Rap antikoerper, Raptor antikoerper, mKIAA1303 antikoerper, RGD1311784 antikoerper, raptor antikoerper, regulatory associated protein of MTOR complex 1 antikoerper, regulatory associated protein of MTOR, complex 1 antikoerper, regulatory associated protein of MTOR, complex 1 L homeolog antikoerper, RPTOR antikoerper, Rptor antikoerper, rptor.L antikoerper, rptor antikoerper

Hintergrund:

Description: This gene encodes a component of a signaling pathway that regulates cell growth in response to nutrient and insulin levels. The encoded protein forms a stoichiometric complex with the mTOR kinase, and also associates with eukaryotic initiation factor 4E-binding protein-1 and ribosomal protein S6 kinase. The protein positively regulates the downstream effector ribosomal protein S6 kinase, and negatively regulates the mTOR kinase. Multiple transcript variants encoding different isoforms have been found for this gene. ,

Aliases: KOG1, Mip1

Molekulargewicht: 149 kDa

Gen-ID: 57521

HGNC: 57521

Pathways: PI3K-Akt Signalweg, RTK Signalweg, AMPK Signaling, Regulation of Muscle Cell Differentiation, Regulation of Cell Size, Skeletal Muscle Fiber Development, Autophagie, BCR Signaling, Warburg Effekt