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HUWE1 Antikörper (AA 3201-3400)

HUWE1 Reaktivität: Human ELISA, IHC (p), IF (cc), IF (p), ICC, IHC (fro) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN1714659
  • Target Alle HUWE1 Antikörper anzeigen
    HUWE1 (HECT, UBA and WWE Domain Containing 1, E3 Ubiquitin Protein Ligase (HUWE1))
    Bindungsspezifität
    • 14
    • 6
    • 5
    • 1
    • 1
    • 1
    AA 3201-3400
    Reaktivität
    • 35
    • 14
    • 12
    Human
    Wirt
    • 32
    • 2
    • 1
    Kaninchen
    Klonalität
    • 33
    • 2
    Polyklonal
    Konjugat
    • 14
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser HUWE1 Antikörper ist unkonjugiert
    Applikation
    • 12
    • 12
    • 11
    • 7
    • 5
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Homologie
    Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Rabbit
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human ARF6
    Isotyp
    IgG
    Top Product
    Discover our top product HUWE1 Primärantikörper
  • Applikationshinweise
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    ICC 1:100-500
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Haltbarkeit
    12 months
  • Target
    HUWE1 (HECT, UBA and WWE Domain Containing 1, E3 Ubiquitin Protein Ligase (HUWE1))
    Andere Bezeichnung
    ARFBP1 (HUWE1 Produkte)
    Synonyme
    ARF-BP1 antikoerper, HECTH9 antikoerper, HSPC272 antikoerper, Ib772 antikoerper, LASU1 antikoerper, MULE antikoerper, URE-B1 antikoerper, UREB1 antikoerper, 5430439H10Rik antikoerper, AU041296 antikoerper, Arf-bp1 antikoerper, C430014N20Rik antikoerper, C80292 antikoerper, Gm1718 antikoerper, Mule antikoerper, Ureb1 antikoerper, HUWE1 antikoerper, si:dkey-242a8.2 antikoerper, Huwe1 antikoerper, mule antikoerper, ib772 antikoerper, lasu1 antikoerper, ureb1 antikoerper, hecth9 antikoerper, arf-bp1 antikoerper, hspc272 antikoerper, HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase antikoerper, HECT, UBA and WWE domain containing 1 antikoerper, E3 ubiquitin-protein ligase HUWE1 antikoerper, HUWE1 antikoerper, Huwe1 antikoerper, huwe1 antikoerper, LOC100123214 antikoerper, LOC100380641 antikoerper
    Hintergrund

    Synonyms: ARF binding protein 1, ARF BP1, ARF-binding protein 1, ARF-BP1, BJ-HCC-24 tumor antigen, E3 ubiquitin protein ligase HUWE1, E3 ubiquitin-protein ligase HUWE1, HECT, HECT domain protein LASU1, HECT UBA and WWE domain containing protein 1, HectH9, Homologous to E6AP carboxyl terminus homologous protein 9, HUWE, Huwe1, HUWE1_HUMAN, Ib772, KIAA0312, KIAA1578, Large structure of UREB1, LASU1, Mcl 1 ubiquitin ligase E3, Mcl-1 ubiquitin ligase E3, MULE, UBA and WWE domain-containing protein 1, Upstream regulatory element-binding protein 1, URE B1, URE-B1, URE-binding protein 1, UREB 1, UREB1.

    Background: E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1. Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair. Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4. Binds to an upstream initiator-like sequence in the preprodynorphin gene. Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN. May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation.

    Gen-ID
    382
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