TAZ Antikörper (AA 1-100)

Produktnummer ABIN1713913

Produktdetails anti-TAZ Antikörper

Target: TAZ (Tafazzin (TAZ))

Bindungsspezifität: AA 1-100

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TAZ Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Flow Cytometry (FACS), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human TAZ

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-TAZ Antikörper (ABIN1713913)

Ukita, Yamaguchi, Ohata, Tamura: "Sclerostin Enhances Adipocyte Differentiation in 3T3-L1 Cells." in: Journal of cellular biochemistry, Vol. 117, Issue 6, pp. 1419-28, (2016) (PubMed).

Sun, Chen, Shi, Qi, Zhao, Zhang: "Prognostic impact of TAZ and ?-catenin expression in adenocarcinoma of the esophagogastric junction." in: Diagnostic pathology, Vol. 9, pp. 125, (2014) (PubMed).

Details zu TAZ

Target: TAZ (Tafazzin (TAZ))

Andere Bezeichnung: TAZ (TAZ Produkte)

Synonyme: wu:fb39f12 antikoerper, zgc:91803 antikoerper, MGC54019 antikoerper, TAZ antikoerper, taz antikoerper, GB11956 antikoerper, Afu2g13960 antikoerper, BTHS antikoerper, CMD3A antikoerper, EFE antikoerper, EFE2 antikoerper, G4.5 antikoerper, LVNCX antikoerper, Taz1 antikoerper, 5031411C02Rik antikoerper, 9130012G04Rik antikoerper, AW107266 antikoerper, AW552613 antikoerper, tafazzin antikoerper, tafazzin L homeolog antikoerper, tafazzin homolog antikoerper, TAZ antikoerper, taz antikoerper, taz.L antikoerper, LOC550948 antikoerper, AFUA_2G13960 antikoerper, AOR_1_318014 antikoerper, Tsp_06712 antikoerper, Taz antikoerper

Hintergrund:

Synonyms: TAZ, WW domain-containing transcription regulator protein 1, Transcriptional coactivator with PDZ-binding motif, WWTR1

Background: Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. Regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition.

Gen-ID: 25937

UniProt: Q9GZV5