FUBP1, FUBP2 (AA 551-644) Antikörper (HRP)
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- Target
- FUBP1, FUBP2
- Bindungsspezifität
- AA 551-644
- Reaktivität
- Maus
-
Wirt
- Kaninchen
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Klonalität
- Polyklonal
-
Konjugat
- HRP
-
Applikation
- Western Blotting (WB), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Spezifität
- This antibody detects both FUBP1 and FUBP2 (KHSRP)
- Kreuzreaktivität
- Maus
- Homologie
- Human,Rat,Dog,Cow,Sheep,Pig,Horse,Rabbit,Zebrafish
- Aufreinigung
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human FUBP1
- Isotyp
- IgG
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-
- Applikationshinweise
-
WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500 - Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
- Format
- Liquid
- Konzentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Konservierungsmittel
- ProClin
- Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Handhabung
- Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Haltbarkeit
- 12 months
-
- Target
- FUBP1, FUBP2
- Andere Bezeichnung
- FUBP1/2
- Hintergrund
-
Synonyms: Far upstream element-binding protein 1, FUBP1, FBP, FUSE-binding protein 1, DNA helicase V, hDH V, Far upstream element-binding protein 2, KHSRP, FUSE-binding protein 2, KH type-splicing regulatory protein, KSRP, p75, FBP2, FUBP2
Background: FUBP1 Regulates MYC expression by binding to a single-stranded far-upstream element (FUSE) upstream of the MYC promoter. May act both as activator and repressor of transcription. FUBP2 Binds to the dendritic targeting element and may play a role in mRNA trafficking. Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3'-UTR, possibly by recruiting degradation machinery to ARE-containing mRNAs.
- Gen-ID
- 8880
- UniProt
- Q96AE4
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