Atic/Aicar Transformylase (AA 351-450) Antikörper (HRP)
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- Target
- Atic/Aicar Transformylase
- Bindungsspezifität
- AA 351-450
- Reaktivität
- Human
-
Wirt
- Kaninchen
-
Klonalität
- Polyklonal
-
Konjugat
- HRP
-
Applikation
- Western Blotting (WB), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Kreuzreaktivität
- Human
- Homologie
- Mouse,Rat,Dog,Cow,Pig,Horse,Rabbit
- Aufreinigung
- Purified by Protein A.
- Immunogen
- KLH conjugated synthetic peptide derived from human ATIC/AICAR transformylase
- Isotyp
- IgG
-
-
- Applikationshinweise
-
WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500 - Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
- Format
- Liquid
- Konzentration
- 1 μg/μL
- Buffer
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- Konservierungsmittel
- ProClin
- Vorsichtsmaßnahmen
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- Handhabung
- Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Haltbarkeit
- 12 months
-
- Target
- Atic/Aicar Transformylase
- Hintergrund
-
Synonyms: 5 aminoimidazole 4 carboxamide 1 beta D ribonucleotide transformylase/inosinicase, 5 aminoimidazole 4 carboxamide ribonucleotide formyltransferase, 5 aminoimidazole 4 carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase, 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase, AICAR, AICAR formyltransferase/IMP cyclohydrolase bunctional enzyme, AICAR transformylase, AICARFT, AICARFT/IMPCHASE, ATIC, Bunctional purine biosynthesis protein PURH, FLJ93545, IMP cyclohydrolase, IMP synthase, IMP synthetase, IMPCHASE, Inosinicase, OK/SW-cl.86, Phosphoribosylaminoimidazolecarboxamide formyltransferase, Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase, PUR9_HUMAN, PURH.
Background: The bifunctional purine biosynthesis protein ATIC (also designated PURH) contains AICAR transformylase and IMP cyclohydrolase activities. AICAR (5-aminoimidazole-4-carboxamide ribonucleotide) transformylase catalyzes the second to last step in purine biosynthesis, playing an important role in the production of nucleotides and IMP. Defects in the ATIC transformylase gene can cause AICA-rebsuria, also designated AICA-ribosiduria, an inborn error in purine biosynthesis that is neurologically cataclysmic. Individuals with AICA-rebosuria accumulate AICA-riboside, also designated ZMP, and its derivatives in erythrocytes and fibroblasts. Patients also excrete very large amounts of AICA-riboside in the urine. Mental retardation, epilepsy, dysmorphic features and congenital blindness are all symptoms of this disease.
- Gen-ID
- 471
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