ANAPC11 Antikörper (AA 1-84) (HRP)

Produktnummer ABIN1712104

Produktdetails anti-ANAPC11 Antikörper (HRP)

Target: ANAPC11 (Anaphase Promoting Complex Subunit 11 (ANAPC11))

Bindungsspezifität: AA 1-84

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ANAPC11 Antikörper ist konjugiert mit HRP

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Homologie: Human,Mouse,Rat,Dog,Sheep,Pig

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human APC11

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handhabung: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu ANAPC11

Target: ANAPC11 (Anaphase Promoting Complex Subunit 11 (ANAPC11))

Andere Bezeichnung: APC11 (ANAPC11 Produkte)

Synonyme: APC11 antikoerper, Apc11p antikoerper, anapc11 antikoerper, RGD1561880 antikoerper, F10A16.17 antikoerper, F10A16_17 antikoerper, anaphase-promoting complex/cyclosome 11 antikoerper, DDBDRAFT_0187183 antikoerper, DDBDRAFT_0231277 antikoerper, DDB_0187183 antikoerper, DDB_0231277 antikoerper, 1110011I19Rik antikoerper, R75218 antikoerper, zgc:153671 antikoerper, si:dkey-237i9.4 antikoerper, anaphase promoting complex subunit 11 antikoerper, anaphase promoting complex subunit 11 L homeolog antikoerper, anaphase-promoting complex/cyclosome 11 antikoerper, anaphase-promoting complex subunit Apc11 antikoerper, ubiquitin-protein ligase Anaphase Promoting Complex antikoerper, hypothetical protein antikoerper, predicted protein antikoerper, anaphase-promoting complex subunit 11 antikoerper, APC11 anaphase promoting complex subunit 11 homolog (yeast) antikoerper, ANAPC11 antikoerper, anapc11.L antikoerper, anapc11 antikoerper, Anapc11 antikoerper, APC11 antikoerper, apc11 antikoerper, CAALFM_CR10610CA antikoerper, LOC9320604 antikoerper, LOC692923 antikoerper

Hintergrund:

Synonyms: ANAPC 11, ANAPC11, Anaphase promoting complex subunit 11, Anaphase promoting complex subunit 11 homolog yeast, Anaphase promoting complex subunit 11 homolog, Anaphase-promoting complex subunit 11, Apc 11, Apc 11p, APC11 anaphase promoting complex subunit 11 homolog yeast, APC11 anaphase promoting complex subunit 11 homolog, APC11, APC11_HUMAN, Apc11p, Cyclosome subunit 11, Hepatocellular carcinoma associated RING finger protein, Hepatocellular carcinoma-associated RING finger protein, HSPC 214, HSPC214, MGC882, Yeast APC 11 homolog, Yeast APC11 homolog.

Background: Comprising more than ten subunits, the anaphase-promoting complex (APC) acts in a cell-cycle dependent manner to promote the separation of sister chromatids during the transition between metaphase and anaphase in mitosis. APC, or cyclosome, accomplishes this progression through the ubiquitination of mitotic cyclins and other regulatory proteins that are targeted for destruction during cell division. APC is phosphorylated, and thus activated, by protein kinases Cdk1/cyclin B and polo-like kinase (Plk). APC is under tight control by a number of regulatory factors, including CDC20, CDH1 and MAD2. Specifically, CDC20 and CDH1 directly bind to APC and activates APC?s cyclin-ubiquitination activity. In contrast, MAD2 inhibits APC by forming a ternary complex with CDC20 and APC, thus preventing APC activation. APC11 is a RING-H2 finger protein that allows for the synthesis of multiubiquitin chains in the presence of Ubiquitin carrier protein 4 (Ubc4) and ubiquitin conjugating enzyme (E2). In addition, a heterodimeric complex of either Ubc4 or UbcH10 with APC11 and APC2 catalyzes the ubiquitination of human securin and cyclin B1.

Gen-ID: 51529