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Glutaredoxin 2 Antikörper (AA 101-164) (HRP)

GRX2 Reaktivität: Human, Ratte WB, ELISA, IHC (p), IHC (fro) Wirt: Kaninchen Polyclonal HRP
Produktnummer ABIN1712066
  • Target Alle Glutaredoxin 2 (GRX2) Antikörper anzeigen
    Glutaredoxin 2 (GRX2)
    Bindungsspezifität
    • 15
    • 6
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 101-164
    Reaktivität
    • 40
    • 22
    • 7
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Human, Ratte
    Wirt
    • 34
    • 6
    Kaninchen
    Klonalität
    • 38
    • 2
    Polyklonal
    Konjugat
    • 21
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser Glutaredoxin 2 Antikörper ist konjugiert mit HRP
    Applikation
    • 33
    • 21
    • 13
    • 13
    • 9
    • 8
    • 6
    • 6
    • 5
    • 3
    • 2
    • 2
    Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Kreuzreaktivität
    Human, Ratte
    Homologie
    Mouse,Dog,Cow,Sheep,Rabbit
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human Glutaredoxin 2
    Isotyp
    IgG
    Top Product
    Discover our top product GRX2 Primärantikörper
  • Applikationshinweise
    WB 1:300-5000
    IHC-P 1:200-400
    IHC-F 1:100-500
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Handhabung
    Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Haltbarkeit
    12 months
  • Target
    Glutaredoxin 2 (GRX2)
    Andere Bezeichnung
    Glutaredoxin 2 (GRX2 Produkte)
    Synonyme
    ECK1049 antikoerper, JW1051 antikoerper, CGI-133 antikoerper, GRX2 antikoerper, 1700010P22Rik antikoerper, AI645710 antikoerper, Grx2 antikoerper, glutaredoxin 2 (Grx2) antikoerper, glutaredoxin Grx2 antikoerper, thioredoxin antikoerper, glutaredoxin 2 antikoerper, glutaredoxin 2 (thioltransferase) antikoerper, grxB antikoerper, grx2 antikoerper, AF_RS10790 antikoerper, GLRX2 antikoerper, Glrx2 antikoerper
    Hintergrund

    Synonyms: GRX2, CGI-133, Glutaredoxin-2, mitochondrial, GLRX2

    Background: Glutathione-dependent oxidoreductase that facilitates the maintenance of mitochondrial redox homeostasis upon induction of apoptosis by oxidative stress. Involved in response to hydrogen peroxide and regulation of apoptosis caused by oxidative stress. Acts as a very efficient catalyst of monothiol reactions because of its high affinity for protein glutathione-mixed disulfides. Can receive electrons not only from glutathione (GSH), but also from thioredoxin reductase supporting both monothiol and dithiol reactions. Efficiently catalyzes both glutathionylation and deglutathionylation of mitochondrial complex I, which in turn regulates the superoxide production by the complex. Overexpression decreases the susceptibility to apoptosis and prevents loss of cardiolipin and cytochrome c release.

    Gen-ID
    51022
    UniProt
    Q9NS18
    Pathways
    Cell RedoxHomeostasis
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