Destrin Antikörper (AA 75-165) (HRP)

Produktnummer ABIN1712033

Produktdetails anti-Destrin Antikörper (HRP)

Target: Destrin (DSTN) (Destrin (Actin Depolymerizing Factor) (DSTN))

Bindungsspezifität: AA 75-165

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Destrin Antikörper ist konjugiert mit HRP

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Homologie: Human,Mouse,Rat,Dog,Cow,Horse,Rabbit,Monkey

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Destrin

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handhabung: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu Destrin

Target: Destrin (DSTN) (Destrin (Actin Depolymerizing Factor) (DSTN))

Andere Bezeichnung: Destrin (DSTN Produkte)

Synonyme: ACTDP antikoerper, ADF antikoerper, bA462D18.2 antikoerper, DSTN antikoerper, LOC100190417 antikoerper, adf antikoerper, actdp antikoerper, ba462d18.2 antikoerper, 2610043P17Rik antikoerper, AU042046 antikoerper, Dsn antikoerper, corn1 antikoerper, sid23p antikoerper, destrin antikoerper, destrin, actin depolymerizing factor antikoerper, destrin antikoerper, destrin, actin depolymerizing factor S homeolog antikoerper, DSTN antikoerper, dstn antikoerper, Dstn antikoerper, dstn.S antikoerper

Hintergrund:

Synonyms: 2610043P17Rik, ACTDP, Actin depolymerizing factor, Actin-depolymerizing factor, ADF, AU042046, bA462D18.2, corn1, DEST_HUMAN, Destrin actin depolymerizing factor, Destrin, DSN, Dstn, Sid 23, sid23p.

Background: Actin-depolymerizing factor (ADF), also known as destrin, is a member of the ADF/Cofilin/destrin superfamily that has the ability to rapidly depolymerize F-Actin in a stoichiometric manner. The Actin-depolymerizing activity of ADF is reversibly controlled by changes in KCl concentration but is insensitive to calcium concentration. ADF depolymerizes F-Actin by interacting directly with F-Actin protomers. ADF shares 71 % sequence homology with Cofilin, however the two proteins differ in their interaction with Actin. The difference in the function of ADF and Cofilin results from the subtle difference in their amino acid sequence rather than possible differences in posttranslational modifications. As a result of different cleavage sites on ADF and Cofilin, the proteins differ in their overall tertiary folds. Sensitivity to polyphosphoinositides may be a common feature in vitro among Actin-binding proteins such as ADF and Cofilin that can bind to G-Actin and regulate the state of Actin polymerization. ADF and Cofilin are Actin-depolymerizing proteins whose activities are possibly regulated by their phosphorylation/dephosphorylation.

Gen-ID: 11034