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DOCK4 Antikörper (AA 1001-1100) (HRP)

DOCK4 Reaktivität: Human ELISA, IHC (p), IHC (fro) Wirt: Kaninchen Polyclonal HRP
Produktnummer ABIN1711661
  • Target Alle DOCK4 Antikörper anzeigen
    DOCK4 (Dedicator of Cytokinesis 4 (DOCK4))
    Bindungsspezifität
    • 14
    • 3
    • 3
    • 2
    • 1
    • 1
    AA 1001-1100
    Reaktivität
    • 33
    • 11
    • 9
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 30
    • 4
    Kaninchen
    Klonalität
    • 31
    • 3
    Polyklonal
    Konjugat
    • 14
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser DOCK4 Antikörper ist konjugiert mit HRP
    Applikation
    • 14
    • 13
    • 9
    • 6
    • 5
    • 4
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Homologie
    Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Chicken,Rabbit
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human DOCK4
    Isotyp
    IgG
    Top Product
    Discover our top product DOCK4 Primärantikörper
  • Applikationshinweise
    IHC-P 1:200-400
    IHC-F 1:100-500
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Handhabung
    Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Haltbarkeit
    12 months
  • Target
    DOCK4 (Dedicator of Cytokinesis 4 (DOCK4))
    Andere Bezeichnung
    DOCK4 (DOCK4 Produkte)
    Synonyme
    DOCK4 antikoerper, 5330406C03 antikoerper, 6330411N01Rik antikoerper, AF263288 antikoerper, C030023J22 antikoerper, mKIAA0716 antikoerper, dedicator of cytokinesis 4 antikoerper, DOCK4 antikoerper, NAEGRDRAFT_81257 antikoerper, Dock4 antikoerper
    Hintergrund

    Synonyms: Dedicator of cytokinesis protein 4, Dock4, DOCK4_HUMAN, KIAA0716.

    Background: DOCK 4 is a cytoplasmic peripheral membrane protein that belongs to the DOCK family of cytokinesis-regulating proteins. Expressed ubiquitously with highest expression in prostate, ovary and skeletal muscle, DOCK 4 functions as a guanine nucleotide exchange factor (GEF) that activates the small GTPase Rap 1 and, via this activation, plays a role in the regulation of adherens junctions between cells. Similar to other DOCK family members, DOCK 4 contains an N-terminal SH3 domain, a C-terminal proline-rich region and two internal DOCK homology regions designated DHR1 and DHR2. Defects in the gene encoding DOCK 4 result in the inactivation of Rap 1 and are, thus, implicated in the pathogenesis of various cancers such as ovarian, prostate, glioma and colorectal carcinomas. Four isoforms of DOCK 4 are expressed due to alternative splicing events.

    Gen-ID
    9732
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