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ARFGEF1 Antikörper (AA 1-200) (HRP)

ARFGEF1 Reaktivität: Maus WB, IHC (p), ELISA, IHC (fro) Wirt: Kaninchen Polyclonal HRP
Produktnummer ABIN1711628
  • Target Alle ARFGEF1 Antikörper anzeigen
    ARFGEF1 (ADP-Ribosylation Factor Guanine Nucleotide-Exchange Factor 1(brefeldin A-Inhibited) (ARFGEF1))
    Bindungsspezifität
    • 14
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 1-200
    Reaktivität
    • 18
    • 16
    • 11
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Maus
    Wirt
    • 29
    • 1
    Kaninchen
    Klonalität
    • 29
    • 1
    Polyklonal
    Konjugat
    • 10
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser ARFGEF1 Antikörper ist konjugiert mit HRP
    Applikation
    • 20
    • 13
    • 13
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro))
    Kreuzreaktivität
    Maus
    Homologie
    Human,Rat,Dog,Cow,Sheep,Pig,Chicken
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human BIG1/ARFGEF1
    Isotyp
    IgG
    Top Product
    Discover our top product ARFGEF1 Primärantikörper
  • Applikationshinweise
    WB 1:300-5000
    IHC-P 1:200-400
    IHC-F 1:100-500
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Handhabung
    Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Haltbarkeit
    12 months
  • Target
    ARFGEF1 (ADP-Ribosylation Factor Guanine Nucleotide-Exchange Factor 1(brefeldin A-Inhibited) (ARFGEF1))
    Andere Bezeichnung
    BIG1/ARFGEF1 (ARFGEF1 Produkte)
    Synonyme
    ARFGEF1 antikoerper, ARFGEP1 antikoerper, BIG1 antikoerper, P200 antikoerper, D130059B05Rik antikoerper, D730028O18Rik antikoerper, RGD1560793 antikoerper, ADP ribosylation factor guanine nucleotide exchange factor 1 antikoerper, brefeldin A-inhibited guanine nucleotide-exchange protein 1 antikoerper, ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited) antikoerper, ARFGEF1 antikoerper, CpipJ_CPIJ004831 antikoerper, Arfgef1 antikoerper
    Hintergrund

    Synonyms: ADPribosylation factor guanine nucleotide exchange factor 1brefeldin A inhibited, ARFGEF1, ARFGEP1, Brefeldin A inhibited GEP 1, Brefeldin A inhibited guanine nucleotide exchange protein 1, p200 ARF GEP1, p200 ARF guanine nucleotide exchange factor, BIG1_HUMAN.

    Background: Guanine nucleotide-exchange proteins (GEPs) accelerate replacement of bound GDP with GTP and thereby activate ADP-ribosylation factors (ARFs), a family of guanine nucleotide-binding proteins that play an important role in intracellular vesicular trafficking. GEPs comprise two major families, large GEPs that are inhibited by brefeldin A (BFA), a protein that effects Golgi structure and a group of smaller GEPs that are insenstive to BFA. Two genes for GEPs found on human chromosomes 8 and 20 encode BFA sensitive GEPs designated BIG1 and BIG2. Both GEPS contain a sec7 domain that is responsible for their brefeldin inhibition and also their catalytic activity. In vivo, BIG1 and BIG2 exist in macromolecular complexes that move between the Golgi membranes and cytosol. BIG2 associates with PKA regulatory subunits, implying that BIG2 may act as an A kinase-anchoring protein (AKAP) that could coordinate the cAMP and ARF regulatory pathways.

    Gen-ID
    10565
    Pathways
    Regulation of Actin Filament Polymerization, Regulation of Carbohydrate Metabolic Process
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