SYNGAP1 Antikörper (Synaptic Ras GTPase Activating Protein 1) (pSer836) (Cy5)

Details for Product anti-SYNGAP1 Antibody No. ABIN1705058
Antigen
  • SYNGAP1
  • Syngap
  • MRD5
  • RASA1
  • RASA5
  • SYNGAP
  • Gm1963
  • synaptic Ras GTPase activating protein 1
  • zinc finger and BTB domain containing 9
  • synaptic Ras GTPase activating protein 1 homolog (rat)
  • SYNGAP1
  • ZBTB9
  • syngap1
  • Syngap1
Epitop
pSer836
14
11
11
10
3
3
1
1
1
Reaktivität
Human, Maus, Ratte (Rattus)
73
60
53
8
7
6
4
4
3
1
1
1
1
Wirt
Kaninchen
51
30
Klonalität
Polyklonal
Konjugat
Dieser SYNGAP1 Antikörper ist konjugiert mit Cy5
5
4
4
3
3
3
3
3
2
2
2
2
2
2
2
2
2
Applikation
Immunofluorescence (Paraffin-embedded Sections) (IF (p))
45
34
25
7
4
3
2
2
1
1
Optionen
Immunogen KLH conjugated synthetic hosphopeptide derived from human SynGAP around the phosphorylation site of Ser836
Isotyp IgG
Reinigung Purified by Protein A.
Plasmids, Primers & others Plasmide, Primers & weitere SYNGAP1 products on genomics-online (e.g. as negative or positive controls)
Antigen
Andere Bezeichnung Syngap (SYNGAP1 Antibody Abstract)
Hintergrund

The PSD-95/SAP 90 family of proteins, which are known to bind to and cluster various membrane proteins, are involved in the organization of synaptic structure. SynGAP (for synaptic GTPase activating protein), a novel synaptic RasGAP, is a brain-specific protein abundant in the cortex, hippocampus and olfactory bulb. SynGAP interacts with all three PDZ domains within PSD-95/ SAP 90 proteins. It represents one of three classes of mammalian RasGAPs and is specifically localized to excitatory synapses possessing NMDA receptors. SynGAP may be involved in the regulation of BDNF as well as Ras signaling. Its activity is inhibited by phosphorylation by CaMKII, which could result in the activation of the MAP kinase pathway.

Synonyms: SynGAP phospho S836, SynGAP phospho Ser836, p-SynGAP Ser836, p-RASA1Ser836, Neuronal RasGAP, p135 SynGAP, Ras GTPase activating protein SynGAP, Ras GTPase-activating protein SynGAP, RASA 1, RASA 5, RASA1, RASA5, SYGP1_HUMAN, Synaptic Ras GAP 1, Synaptic Ras GTPase activating protein 1, Synaptic Ras GTPase activating protein 1 homolog, Synaptic Ras GTPase activating protein 135 kDa, synaptic Ras GTPase activating protein, Synaptic Ras GTPase-activating protein 1, Synaptic Ras-GAP 1, SYNGAP 1, SYNGAP1, DKFZp761G1421, KIAA1938, MRD5, OTTHUMP00000064825.

Gen-ID 8831
Pathways Regulation of long-term Neuronal Synaptic Plasticity
Applikations-hinweise IF(IHC-P) 1:50-200
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Lagerung 4 °C
Informationen zur Lagerung Store at 4°C
Haltbarkeit 12 months
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