Thrombin Activation Peptide Fragment 1 Antikörper (Cy5)

Details zu Produkt Nr. ABIN1705056
Antigen
  • Cf-2
  • Cf2
  • FII
  • thrombin
  • coagulation factor II
  • F2
Reaktivität
Human, Maus, Ratte (Rattus)
14
14
14
Wirt
Kaninchen
14
Klonalität
Polyklonal
Konjugat
Cy5
1
1
1
1
1
1
1
1
1
1
1
1
1
Applikation
Immunofluorescence (Paraffin-embedded Sections) (IF (p))
12
3
3
Optionen
Immunogen KLH conjugated synthetic peptide derived from human Thrombin Activation peptide fragment 1
Isotyp IgG
Reinigung Purified by Protein A.
Antigen
Hintergrund

Thrombin is the final protease in the blood coagulation cascade and serves both pro- and anticoagulant functions through the cleavage of several targets. The ability of thrombin to specifically recognize a wide range of substrates derives from interactions which occur outside of the active site of thrombin. Thrombin possesses two anion binding exosites which mediate many of its interactions with cofactors and substrates, and although many structures of thrombin have been solved, few such interactions have been described in molecular detail. Glycosaminoglycan binding to exosite II of thrombin plays a major role in switching off the procoagulant functions of thrombin by mediating its irreversible inhibition by circulating serpins and by its binding to the endothelial cell surface receptor thrombomodulin.

Synonyms: Activation peptide fragment 1, coagulation factor II, prothrombin, F2, Cf-2, Cf2, FII, F 2, coagulation factor II thrombin, Coagulation factor II, Coagulation factor II precursor, F2, Factor II, Factor-II, Prothrombin, prothrombin B-chain, PT, serine protease, THRB, THRB_HUMAN, Thrombin.

Gen-ID 2147
Applikations-hinweise IF(IHC-P) 1:50-200
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Lagerung 4 °C
Informationen zur Lagerung Store at 4°C
Haltbarkeit 12 months
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