Sorting Nexin 2 (SNX2) Antikörper (Cy5)

Details zu Produkt Nr. ABIN1704993
Antigen
  • snx2
  • MGC64590
  • SNX2
  • LOC100219194
  • TRG-9
  • 0610030A03Rik
  • zgc:123293
  • sorting nexin 2 S homeolog
  • sorting nexin 2
  • snx2.S
  • SNX2
  • BACOIKO006_25
  • snx2
  • Snx2
Reaktivität
Human, Maus, Ratte (Rattus)
62
27
22
5
4
4
4
2
2
2
2
1
1
1
1
Wirt
Kaninchen
60
2
Klonalität
Polyklonal
Konjugat
Cy5
4
3
3
2
2
2
2
2
2
2
2
1
1
1
1
1
1
Applikation
Immunofluorescence (Paraffin-embedded Sections) (IF (p))
44
19
12
11
10
1
1
Optionen
Immunogen KLH conjugated synthetic peptide derived from human SNX2
Isotyp IgG
Reinigung Purified by Protein A.
Antigen
Andere Bezeichnung Snx2 (SNX2 Antibody Abstract)
Hintergrund

Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:16179610). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex (PubMed:17101778). The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity (PubMed:23085988). Required for retrograde endosome-to-TGN transport of TGN38 (PubMed:20138391). Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation, the function is dependent on GEF activity of KALRN (PubMed:20604901).

Subcellular location: Membrane bound

Synonyms: TRG-9, Sorting nexin-2, Transformation-related gene 9 protein, SNX2, TRG9

Gen-ID 6643
UniProt O60749
Applikations-hinweise IF(IHC-P) 1:50-200
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Lagerung 4 °C
Informationen zur Lagerung Store at 4°C
Haltbarkeit 12 months
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