NOBOX Antikörper (NOBOX Oogenesis Homeobox) (Cy5)

Details for Product anti-NOBOX Antibody No. ABIN1704975
Antigen
  • OG-2
  • OG2
  • OG2X
  • POF5
  • TCAG_12042
  • Og2x
  • RGD1563929
  • NOBOX oogenesis homeobox
  • NOBOX
  • Nobox
Reaktivität
Human, Maus, Ratte (Rattus)
28
17
14
1
Wirt
Kaninchen
27
3
Klonalität
Polyklonal
Konjugat
Dieser NOBOX Antikörper ist konjugiert mit Cy5
1
1
1
1
1
1
1
1
1
1
1
1
1
Applikation
Immunofluorescence (Paraffin-embedded Sections) (IF (p))
19
12
6
5
3
Optionen
Immunogen KLH conjugated synthetic peptide derived from human NOBOX
Isotyp IgG
Reinigung Purified by Protein A.
Plasmids, Primers & others Plasmide, Primers & weitere NOBOX products on genomics-online (e.g. as negative or positive controls)
Antigen
Andere Bezeichnung Nobox (NOBOX Antibody Abstract)
Hintergrund

Early ovarian folliculogenesis is characterized by the breakdown of germ cell clusters and formation of primordial follicles. The cessation of ovarian function under the age of 40 years results in premature ovarian failure (POF) and is accompanied by amenorrhea, hypoestrogenism and elevated serum gonadotropin concentrations. 1 % of all women are affected by POF, and mutations in a few genes, including inhibin? fsh receptor and the LH/choriogonadotropin receptor have been linked to POF. In addition, several germ cell specific genes and downstream transcription factors are thought to play and important role in human oogenesis. NOBOX (newborn ovary homeobox gene), an ooctye-specific homeobox gene, is a critical protein involved in early folliculogenesis. Missense mutations have been shown to cause nonsyndromic ovarian failure by disrupting the NOBOX proteins ability to bind to NOBOX DNA-binding element (NBE), and thereby inhibiting its regulation of Pou5f1 and GDF-9. NOBOX expression in the ovary is oocyte specific, but it shows expression in adult testis and pancreas as well.

Synonyms: Homeobox protein NOBOX, Nobox, NOBOX Oogenesis Homeobox, NOBOX_HUMAN, OG-2, OG2, Og2x, POF5, TCAG_12042.

Gen-ID 135935
Applikations-hinweise IF(IHC-P) 1:50-200
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Lagerung 4 °C
Informationen zur Lagerung Store at 4°C
Haltbarkeit 12 months
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