Heparanase (HPSE) Antikörper (Cy5)

Details zu Produkt Nr. ABIN1704949
Antigen
  • im:7144134
  • hpa
  • hpa1
  • hpr1
  • hpse1
  • hse1
  • HPSE
  • HPA
  • HPA1
  • HPR1
  • HPSE1
  • HSE1
  • Hpa
  • Hpr1
  • Hep
  • heparanase
  • HPSE
  • hpse
  • Hpse
Reaktivität
Human, Maus, Ratte (Rattus)
168
87
58
3
3
3
2
2
1
Wirt
Kaninchen
175
22
Klonalität
Polyklonal
Konjugat
Cy5
21
9
6
4
4
4
4
4
3
2
2
2
2
2
2
2
2
2
2
1
1
1
Applikation
Immunofluorescence (Paraffin-embedded Sections) (IF (p))
139
56
49
25
17
16
15
10
7
6
4
2
1
Optionen
Immunogen KLH conjugated synthetic peptide derived from human Heparanase
Isotyp IgG
Reinigung Purified by Protein A.
Antigen
Andere Bezeichnung Heparanase (HPSE Antibody Abstract)
Hintergrund

Heparanase is an endo-beta-D-glucuronidase, which degrades heparan sulfate side chains of heparan sulfate proteoglycans (HSPGs) in the extracellular matrix. Heparanase plays an important role in ECM degradation, facilitating the migration and extravasations of tumor cells and inflammatory leukocytes. Upon degradation, heparanase releases growth factors and cytokines that stimulate cell proliferation and chemotaxis. Heparanase is a heterodimer comprised of a 50 kDa subunit harboring the active site and an 8 kDa subunit. It is produced as a latent 65 kDa precursor and proteolytically processed to its active form. Heparanase is highly expressed in myeloid leukocytes (i.e. neutrophils) in platelets and in human placenta. Human heparanase was found to be upregulated in various types of primary tumors, correlating in some cases with increased tumor invasiveness and vascularity and with poor prospective survival.

Synonyms: Heparanase 50 kDa subunit, heparanase, heparanase1, heparanase-1, heparanase 1, Endo glucoronidase, Endo glucoronidase, Endo-glucoronidase, HPSE_HUMAN, Heparanase1, Heparanase 1, HEP, Hpa 1, HPA, Hpa1, HPR 1, HPR1, HPSE 1, HPSE, HPSE1, HSE 1, HSE1.

Pathways Glycosaminoglycan Metabolic Process
Applikations-hinweise IF(IHC-P) 1:50-200
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Lagerung 4 °C
Informationen zur Lagerung Store at 4°C
Haltbarkeit 12 months
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