Fukutin Antikörper (FKTN) (Cy5)

Details for Product anti-FKTN Antibody No. ABIN1704897
Antigen
  • FCMD
  • fcmd
  • im:7163166
  • zgc:162828
  • FKTN
  • CMD1X
  • LGMD2M
  • MDDGA4
  • MDDGB4
  • MDDGC4
  • D830030O17Rik
  • Fcmd
  • fukutin
  • fukutin S homeolog
  • Fukutin
  • FKTN
  • fktn
  • fktn.S
  • Bm1_09375
  • Bm1_09380
  • Bm1_44655
  • Fktn
Reaktivität
Human, Maus, Ratte (Rattus)
63
45
24
7
6
5
5
4
3
3
2
1
1
Wirt
Kaninchen
69
2
Klonalität
Polyklonal
Konjugat
Dieser Fukutin Antikörper ist konjugiert mit Cy5
4
3
3
2
2
2
2
2
2
2
2
1
1
1
1
1
1
Applikation
Immunofluorescence (Paraffin-embedded Sections) (IF (p))
52
33
23
12
12
9
6
1
1
1
1
Optionen
Immunogen KLH conjugated synthetic peptide derived from human Fukutin
Isotyp IgG
Reinigung Purified by Protein A.
Plasmids, Primers & others Plasmide, Primers & weitere Fukutin products on genomics-online (e.g. as negative or positive controls)
Antigen
Andere Bezeichnung Fukutin (FKTN Antibody Abstract)
Hintergrund

Fukutin, a secreted protein, is expressed in various tissues in normal individuals. Fukutin colocalizes with a Golgi marker and a granular cytoplasmic distribution, suggesting that fukutin passes through the Golgi before being packaged into secretory vesicles. Fukutin may be located in the extracellular matrix, where it interacts with and reinforces a large complex encompassing the outside and inside of muscle membranes, alternatively, as a secreted protein, fukutin may cause muscular dystrophy by an unknown mechanism. The fukutin gene is expressed at similar levels in control fetal and adult brain, but is much reduced in Fukuyama congenital muscular dystrophy (FCMD) brains. Fukutin deficiency affects the modification of glycosylation of DAG1 (i±-dystroglycan), which then cannot localize or function properly and may be degraded or eluted from the extracellular surface membrane of the muscle fiber. FCMD is the first human disease known to be caused by an ancient retrotransposal integration. The gene which encodes fukutin maps to human chromosome 9q31.

Synonyms: C10orf125, Chromosome 10 open reading frame 125, FUCM_HUMAN, Fucose mutarotase, FUCU, Protein fucU homolog.

Gen-ID 282969
Pathways Regulation of Carbohydrate Metabolic Process
Applikations-hinweise IF(IHC-P) 1:50-200
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Lagerung 4 °C
Informationen zur Lagerung Store at 4°C
Haltbarkeit 12 months
Haben Sie etwas anderes gesucht?