Dock5 Antikörper (Dedicator of Cytokinesis 5) (Cy5)

Details for Product anti-Dock5 Antibody No. ABIN1704558
Antigen
  • 1110060D06Rik
  • AI666732
  • AI956923
  • BC016533
  • E130320D18
  • lr2
  • rlc
  • dedicator of cytokinesis 5
  • DOCK5
  • dock5
  • NAEGRDRAFT_78815
  • Dock5
Reaktivität
Human, Maus, Ratte (Rattus)
22
18
14
Wirt
Kaninchen
24
Klonalität
Polyklonal
Konjugat
Dieser Dock5 Antikörper ist konjugiert mit Cy5
2
2
2
1
1
1
1
1
1
1
1
1
1
Applikation
Immunofluorescence (Paraffin-embedded Sections) (IF (p))
12
8
6
4
3
1
1
1
Optionen
Immunogen KLH conjugated synthetic peptide derived from human DOCK5
Isotyp IgG
Reinigung Purified by Protein A.
Plasmids, Primers & others Plasmide, Primers & weitere Dock5 products on genomics-online (e.g. as negative or positive controls)
Antigen
Andere Bezeichnung Dock5 (Dock5 Antibody Abstract)
Hintergrund

DOCK 5 is a 1,870 amino acid protein belonging to the DOCK family of cytokinesis-regulating proteins. This cytoplasmic peripheral membrane protein activates Rac 1 and Rac 2 small GTPases, while presumably acting as a guanine nucleotide exchange factor (GEF), which exchanges bound GDP for free GTP. DOCK 5 contains one DHR-1 (CZH-1) domain, one DHR-2 (CZH-2) domain and one SH3 domain. The DHR-2 domain is a putative GEF activity mediator. In mice, spontaneous mutation of the gene encoding DOCK 5 leads to deletion of the DHR-1 domain, which functions to bind phospholipids and assists in protein-protein interactions, resulting in rupture of lens cataract (RLC). Due to siRNA knockdown studies, it is suspected that DOCK 5 may also be an important mediator of CrkII/CrkL regulation of Caco-2 migration and spreading on COL4. There are two isoforms of DOCK 5 that exist as a result of alternative splicing events.

Synonyms: Dedicator of cytokinesis 5, Dedicator of cytokinesis protein 5, DKFZp451J181, DKFZp779M164, DKFZp781J211, Dock 5, DOCK5_HUMAN.

Gen-ID 80005
Applikations-hinweise IF(IHC-P) 1:50-200
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Lagerung 4 °C
Informationen zur Lagerung Store at 4°C
Haltbarkeit 12 months
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