Latent transforming growth factor-beta 1 binding protein 1 (LTBP-1), a heavy glycoprotein, is part of the platelet-derived TGF-beta 1 complex. LTBP-1 serves as an anchor for latent TGF-beta in the extracellular matrix and is a component of microfibrillar structures. Cleavage of LTBP results in LTBP-1, which may sequester latent TGF-beta in the extracellular matrix and regulate its activation. LTBP-1 mRNA is enriched in ovarian carcinoma tissues and highly expressed in serous and mucinous adenocarcinomas.
Synonyms: 9430031G15Rik, 9830146M04, Latent transforming growth factor beta binding protein 1, Latent-transforming growth factor beta-binding protein 1, Latent-transforming growth factor beta-binding protein, isoform 1L, Latent-transforming growth factor beta-binding protein, isoform 1S, LBT1S, LTBP-1, Ltbp1, LTBP1_HUMAN, MGC163161, TGF-beta1-BP-1, Tgfb, Transforming growth factor beta-1-binding protein 1, Transforming growth factor beta-1-masking protein large subunit.