GIT2 Antikörper (G Protein-Coupled Receptor Kinase Interactor 2) (Cy5)

Details for Product anti-GIT2 Antibody No. ABIN1704499
Antigen
  • CAT-2
  • CAT2
  • cat-2
  • xgit2
  • git2
  • si:dkey-234h16.4
  • 1500036H07Rik
  • 5830420E16Rik
  • 6430510B20Rik
  • 9630056M03Rik
  • B230104M05Rik
  • mKIAA0148
  • zgc:158416
  • GIT ArfGAP 2
  • G protein-coupled receptor kinase interacting ArfGAP 2
  • G protein-coupled receptor kinase interacting ArfGAP 2a
  • G protein-coupled receptor kinase-interactor 2
  • G protein-coupled receptor kinase interacting ArfGAP 2 L homeolog
  • G protein-coupled receptor kinase interacting ArfGAP 2b
  • GIT2
  • git2
  • git2a
  • Git2
  • git2.L
  • git2b
Reaktivität
Human, Maus, Ratte (Rattus)
88
38
38
5
4
2
2
2
2
2
1
1
1
Wirt
Kaninchen
74
17
Klonalität
Polyklonal
Konjugat
Dieser GIT2 Antikörper ist konjugiert mit Cy5
4
3
3
3
3
3
2
2
2
1
1
1
1
1
Applikation
Immunofluorescence (Paraffin-embedded Sections) (IF (p))
54
30
14
12
12
12
4
4
2
2
Optionen
Immunogen KLH conjugated synthetic peptide derived from human GIT2
Isotyp IgG
Reinigung Purified by Protein A.
Plasmids, Primers & others Plasmide, Primers & weitere GIT2 products on genomics-online (e.g. as negative or positive controls)
Antigen
Andere Bezeichnung Git2 (GIT2 Antibody Abstract)
Hintergrund

Heterotrimeric G protein-mediated signal transduction is a dynamically regulated process with the intensity of signal decreasing over time despite the continued presence of the agonist (1,2). G protein-coupled receptor kinases (GRKs) are activated by activated G protein-coupled receptors, and they function to phosphorylate and inactivate cell surface receptors in the heterotrimeric G protein signaling cascade (3,4). GIT1 (for GRK-interactor 1) and GIT2 are GTPase-activating proteins (GAP) for members of the ADP ribosylation factor (ARF) family of small GTP-binding proteins, which are involved in vesicular trafficking (5,6). GIT1 overexpression results in reduced internalization and resensitization of b2-adrenergic receptor, thus reducing b2-adrenergic receptor signaling (5).

Synonyms: ARF GAP GIT2, ARF GTPase activating protein GIT2, ARF GTPase-activating protein GIT2, CAT 2, CAT-2, CAT2, Cool associated tyrosine phosphorylated protein 2, Cool interacting tyrosine phosphorylated protein 2, Cool-interacting tyrosine-phosphorylated protein 2, DKFZp686G01261, G protein coupled receptor kinase interacting ArfGAP 2, G protein coupled receptor kinase interactor 2, G protein-coupled receptor kinase-interactor 2, GIT 2, GIT2, GIT2_HUMAN, GRK interacting protein 2, GRK-interacting protein 2, KIAA0148, MGC760, ARF GTPase-activating protein GIT2, Cool-interacting tyrosine-phosphorylated protein 2, G protein-coupled receptor kinase-interactor 2.

Gen-ID 9815
Pathways Regulation of G-Protein Coupled Receptor Protein Signaling
Applikations-hinweise IF(IHC-P) 1:50-200
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Lagerung 4 °C
Informationen zur Lagerung Store at 4°C
Haltbarkeit 12 months
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