FZD3 Antikörper (Frizzled Family Receptor 3) (AA 150-200) (Cy5)

Details for Product anti-FZD3 Antibody No. ABIN1704293
Antigen
Epitop
AA 150-200
15
15
11
10
7
7
4
3
3
3
2
2
2
2
1
1
1
1
1
1
1
Reaktivität
Human, Maus, Ratte (Rattus)
105
57
24
Wirt
Kaninchen
90
9
6
4
Klonalität
Polyklonal
Konjugat
Dieser FZD3 Antikörper ist konjugiert mit Cy5
7
4
4
3
3
3
2
2
2
2
2
2
1
1
1
1
Applikation
Immunofluorescence (Paraffin-embedded Sections) (IF (p))
69
56
24
21
12
12
5
4
4
2
2
1
Optionen
Immunogen KLH conjugated synthetic peptide derived from human FZD3/Frizzled 3
Isotyp IgG
Reinigung Purified by Protein A.
Antigen
Andere Bezeichnung FZD3/Frizzled 3 (FZD3 Antibody Abstract)
Hintergrund

Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.

Subcellular location: Extracellular

Synonyms: Fz-3, Frizzled-3, hFz3, FZD3

Gen-ID 7976
UniProt Q9NPG1
Pathways WNT Signalweg, Tube Formation
Applikations-hinweise IF(IHC-P) 1:50-200
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Lagerung 4 °C
Informationen zur Lagerung Store at 4°C
Haltbarkeit 12 months