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GMEB2 Antikörper (AA 101-200) (Cy5)

GMEB2 Reaktivität: Maus WB, IF (cc), IF (p) Wirt: Kaninchen Polyclonal Cy5
Produktnummer ABIN1704179
  • Target Alle GMEB2 Antikörper anzeigen
    GMEB2 (Glucocorticoid Modulatory Element Binding Protein 2 (GMEB2))
    Bindungsspezifität
    • 14
    • 2
    • 1
    • 1
    AA 101-200
    Reaktivität
    • 25
    • 15
    • 11
    • 2
    • 2
    • 2
    • 2
    • 1
    Maus
    Wirt
    • 29
    Kaninchen
    Klonalität
    • 29
    Polyklonal
    Konjugat
    • 9
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser GMEB2 Antikörper ist konjugiert mit Cy5
    Applikation
    • 20
    • 12
    • 12
    • 6
    • 5
    • 5
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Kreuzreaktivität
    Maus
    Homologie
    Human,Rat,Dog,Cow,Sheep,Horse,Chicken,Rabbit
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human GMEB2
    Isotyp
    IgG
    Top Product
    Discover our top product GMEB2 Primärantikörper
  • Applikationshinweise
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Haltbarkeit
    12 months
  • Target
    GMEB2 (Glucocorticoid Modulatory Element Binding Protein 2 (GMEB2))
    Andere Bezeichnung
    GMEB2 (GMEB2 Produkte)
    Synonyme
    GMEB2 antikoerper, P79PIF antikoerper, PIF79 antikoerper, AI839884 antikoerper, glucocorticoid modulatory element binding protein 2 antikoerper, glucocorticoid modulatory element binding protein 2 S homeolog antikoerper, GMEB2 antikoerper, gmeb2.S antikoerper, Gmeb2 antikoerper
    Hintergrund

    Synonyms: GMEB2, DNA binding protein p79P, DNA-binding protein p79P, Glucocorticoid modulatory element binding protein 2, Glucocorticoid modulatory element-binding protein 2, GMEB 2, GMEB-2, Gmeb2, GMEB2_HUMAN, KIAA1269, P79P, Parvovirus initiation factor p79, P p79, P79, RP4 663D7.1.

    Background: GMEB-2 is a DNA-binding protein that plays a crucial role modulating transcription upon activation by steroid hormones. GMEB-2 is ubiquitously expressed with preferential expression in developmentally important tissues, such as testis, bone marrow, placenta and fetal tissues. It localizes to the nucleus and cytoplasm and contains a SAND domain near its N-terminus and a C-terminal coiled coil structure. GMEB-2 functions as a homodimer or as a heterodimer with GMEB-1. The formed complex specifically binds to glucocorticoid modulatory elements (GME) in the promoter region of target genes and recruits the histone acetylase CREB binding protein (CBP) during glucocorticoid signaling. This acts to increase sensitivity to low concentrations of glucocorticoids. In addition, GMEB-2 functions as an auxiliary factor required for parvovirus replication.

    Gen-ID
    26205
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