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FRAT2 Antikörper (AA 131-230) (Cy3)

FRAT2 Reaktivität: Maus WB, IF (cc), IF (p) Wirt: Kaninchen Polyclonal Cy3
Produktnummer ABIN1702849
  • Target Alle FRAT2 Antikörper anzeigen
    FRAT2 (Frequently Rearranged in Advanced T-Cell Lymphomas 2 (FRAT2))
    Bindungsspezifität
    • 14
    • 9
    • 8
    • 7
    • 1
    AA 131-230
    Reaktivität
    • 17
    • 14
    Maus
    Wirt
    • 29
    • 1
    • 1
    Kaninchen
    Klonalität
    • 31
    Polyklonal
    Konjugat
    • 8
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser FRAT2 Antikörper ist konjugiert mit Cy3
    Applikation
    • 30
    • 16
    • 14
    • 13
    • 12
    • 12
    • 7
    • 6
    • 3
    • 1
    Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Kreuzreaktivität
    Maus
    Homologie
    Human,Rat,Dog,Cow,Sheep
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human FRAT2
    Isotyp
    IgG
    Top Product
    Discover our top product FRAT2 Primärantikörper
  • Applikationshinweise
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Haltbarkeit
    12 months
  • Target
    FRAT2 (Frequently Rearranged in Advanced T-Cell Lymphomas 2 (FRAT2))
    Andere Bezeichnung
    FRAT2 (FRAT2 Produkte)
    Synonyme
    FRAT2 antikoerper, FRAT2, WNT signaling pathway regulator antikoerper, frequently rearranged in advanced T cell lymphomas 2 antikoerper, frequently rearranged in advanced T-cell lymphomas 2 antikoerper, FRAT2 antikoerper, Frat2 antikoerper
    Hintergrund

    Synonyms: Frequently rearranged in advanced T-cell lymphomas 2 antibodyGSK-3 binding protein FRAT2, FRAT2_HUMAN.

    Background: FRAT1 and FRAT2 were originally characterized as proteins frequently rearranged in advanced T cell lymphoma, and they have since been identified as proto-oncogenes involved in tumorigenesis. These proteins share significant homology with the Xenopus glycogen synthase kinase-3 (xGSK-3) binding protein, which is designated GBP and is essential for the formation of the dorsal-ventral axis during embryonic development. Establishment of these embryonic axes is mediated by the Wnt intracellular signaling pathway. Wnt signaling is regulated in part by the activity of GSK-3, which phosphorylates and thereby facilitates the degradation of ?catenin. GBP binds to GSK-3 and inhibits this phosphorylation, resulting in the accumulation of ?catenin and the subsequent transcription of Wnt target genes. Like GBP, FRAT2 has been shown to bind xGSK-3, suggesting that FRAT1 and FRAT2 may be GSK-3 regulatory proteins.

    Gen-ID
    23401
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