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GUCY1A2 Antikörper (AA 401-500) (Alexa Fluor 647)

Reaktivität: Human WB, IF (cc), IF (p) Wirt: Kaninchen Polyclonal Alexa Fluor 647
Produktnummer ABIN1699511
  • Target Alle GUCY1A2 Produkte
    GUCY1A2 (Guanylyl Cyclase alpha 2)
    Bindungsspezifität
    • 14
    • 4
    • 2
    • 1
    • 1
    AA 401-500
    Reaktivität
    • 19
    • 3
    • 2
    Human
    Wirt
    • 19
    Kaninchen
    Klonalität
    • 19
    Polyklonal
    Konjugat
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser GUCY1A2 Antikörper ist konjugiert mit Alexa Fluor 647
    Applikation
    • 18
    • 12
    • 12
    • 6
    • 5
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Homologie
    Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Rabbit
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human Guanylyl Cyclase alpha 2
    Isotyp
    IgG
  • Applikationshinweise
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Haltbarkeit
    12 months
  • Target
    GUCY1A2 (Guanylyl Cyclase alpha 2)
    Abstract
    GUCY1A2 Produkte
    Synonyme
    GC-SA2 antikoerper, GUC1A2 antikoerper, guanylate cyclase 1 soluble subunit alpha 2 antikoerper, GUCY1A2 antikoerper
    Hintergrund

    Synonyms: GC SA2, GCS-alpha 2, GUC1A2, GUCSA2, GCYA2_HUMAN.

    Background: Guanylate cyclases belong to the adenylyl cyclase class-4/guanylyl cyclase family. There are two forms of guanylate cyclase. The soluble form, known as GCS or sGC, act as receptors for nitric oxide (NO). The membrane-bound receptor form, known as GC, are peptide hormone receptors. GCS is a cGMP-synthesizing enzyme, which is the major receptor for the neurotransmitter nitric oxide. It plays a crucial role in smooth muscle contractility, platelet reactivity and neurotransmission. GCS is a heme-containing heterodimer, consisting of one alpha subunit and one beta subunit. The heme moeity mediates NO activation, and this heme group also binds carbon monoxide (CO), which weakly stimulates the enzyme. Both NO and CO stimulation are enhanced by the allosteric activator 3-(5'-hydroxymethyl-2'furyl)-benzyl-indazole, YC-1. YC-1 can also stimulate GCS in a NO-independent manner. Both alpha and beta subunits are required for cGMP generation, and at least two isoforms exist for each subunit. Heterodimers consisting of alpha-1/beta-1 and alpha-2/beta-1 have been identified, and both display similar enzymatic activity. The distribution of the beta-2 subunit seems to be much more restricted than the beta-1 subunit, with predominant expression in kidney and liver.

    Gen-ID
    2977
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