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GARNL1 Antikörper (AA 631-730) (Alexa Fluor 555)

RALGAPA1 Reaktivität: Ratte IF (cc), IF (p) Wirt: Kaninchen Polyclonal Alexa Fluor 555
Produktnummer ABIN1697055
  • Target Alle GARNL1 (RALGAPA1) Antikörper anzeigen
    GARNL1 (RALGAPA1) (Ral GTPase Activating Protein, alpha Subunit 1 (Catalytic) (RALGAPA1))
    Bindungsspezifität
    • 14
    • 1
    • 1
    • 1
    AA 631-730
    Reaktivität
    • 23
    • 14
    • 10
    Ratte
    Wirt
    • 26
    • 2
    Kaninchen
    Klonalität
    • 26
    • 2
    Polyklonal
    Konjugat
    • 8
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser GARNL1 Antikörper ist konjugiert mit Alexa Fluor 555
    Applikation
    • 12
    • 12
    • 5
    • 5
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Kreuzreaktivität
    Ratte
    Homologie
    Human,Mouse,Dog,Cow,Sheep,Pig,Horse,Chicken
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human GARNL1
    Isotyp
    IgG
    Top Product
    Discover our top product RALGAPA1 Primärantikörper
  • Applikationshinweise
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Haltbarkeit
    12 months
  • Target
    GARNL1 (RALGAPA1) (Ral GTPase Activating Protein, alpha Subunit 1 (Catalytic) (RALGAPA1))
    Andere Bezeichnung
    GARNL1 (RALGAPA1 Produkte)
    Synonyme
    GARNL1 antikoerper, GRIPE antikoerper, TULIP1 antikoerper, Garnl1 antikoerper, Tulip1 antikoerper, tulip1 antikoerper, tulip1.2 antikoerper, 2310003F20Rik antikoerper, 4930400K19Rik antikoerper, AI563624 antikoerper, mKIAA0884 antikoerper, p240 antikoerper, Ral GTPase activating protein catalytic alpha subunit 1 antikoerper, Ral GTPase activating protein, alpha subunit 1 (catalytic) antikoerper, Ral GTPase activating protein, alpha subunit 1 antikoerper, RALGAPA1 antikoerper, Ralgapa1 antikoerper, ralgapa1 antikoerper
    Hintergrund

    Synonyms: DKFZp566D133, DKFZp667F074, GAP related interacting partner to E12, GARN L1, GARNL 1, GRIPE, GTPase activating Rap/RanGAP domain like 1, KIAA0884, Tuberin like protein 1, TULIP 1. TULIP1, RGPA1_HUMAN.

    Background: GARNL1 is expressed during embryogenesis with E12. During development, GARNL1 expression decreases, persisting at high levels only in neurons of the adult brain. GARNL1 localizes to the cytoplasm where it may play a role regulating GTP hydrolysis of proteins such as Ran and Rap. GARNL1 is imported to the nucleus via dimerization with E12. GARNL1 interacts with the HLH region of E12 and may function to negatively regulate the transcription of E12-dependent downstream target genes. This suggests that at least a portion of the function of GARNL1 is dependent upon its association with E12. GARNL1 may also associate with other HLH proteins and influence a variety of HLH signaling cascades. In adult brain, GARNL1 activity does not involve E12 and therefore it may serve a different function in developed neural tissue.

    Gen-ID
    253959
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