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SCIMP Antikörper (AA 1-100) (Alexa Fluor 488)

SCIMP Reaktivität: Human IF (cc), IF (p) Wirt: Kaninchen Polyclonal Alexa Fluor 488
Produktnummer ABIN1694757
  • Target Alle SCIMP Antikörper anzeigen
    SCIMP (SLP Adaptor and CSK Interacting Membrane Protein (SCIMP))
    Bindungsspezifität
    • 14
    • 4
    AA 1-100
    Reaktivität
    Human
    Wirt
    • 19
    • 4
    Kaninchen
    Klonalität
    • 19
    • 4
    Polyklonal
    Konjugat
    • 5
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser SCIMP Antikörper ist konjugiert mit Alexa Fluor 488
    Applikation
    • 12
    • 12
    • 6
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Kreuzreaktivität
    Human
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human C17orf87
    Isotyp
    IgG
    Top Product
    Discover our top product SCIMP Primärantikörper
  • Applikationshinweise
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Haltbarkeit
    12 months
  • Target
    SCIMP (SLP Adaptor and CSK Interacting Membrane Protein (SCIMP))
    Andere Bezeichnung
    C17orf87 (SCIMP Produkte)
    Synonyme
    C17orf87 antikoerper, UNQ5783 antikoerper, A430084P05Rik antikoerper, SLP adaptor and CSK interacting membrane protein antikoerper, SCIMP antikoerper, Scimp antikoerper
    Hintergrund

    Synonyms: C17orf87, CQ087_HUMAN, DTFT5783, SCIMP, SLP adaptor and CSK interacting membrane protein, SLP65/SLP76, Transmembrane protein C17orf87, UNQ5783, UNQ5783/PRO16090.

    Background: C17orf87 (chromosome 17 open reading frame 87) is a 145 amino acid protein that is encoded by a gene mapping to human chromosome 17. Chromosome 17 makes up over 2.5 % of the human genome with about 81 million bases encoding over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes. Chromosome 17 is also linked to neurofibromatosis, a condition characterized by neural and epidermal lesions, and dysregulated Schwann cell growth. Alexander disease, Birt-Hogg-Dube syndrome and Canavan disease are also associated with chromosome 17.

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