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SETD2 Antikörper (AA 803-1103)

SETD2 Reaktivität: Human WB, IF Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN1682666
  • Target Alle SETD2 Antikörper anzeigen
    SETD2 (SET Domain Containing 2 (SETD2))
    Bindungsspezifität
    • 9
    • 7
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 803-1103
    Reaktivität
    • 27
    • 7
    • 5
    • 2
    • 2
    • 2
    Human
    Wirt
    • 23
    • 3
    • 1
    Kaninchen
    Klonalität
    • 24
    • 3
    Polyklonal
    Konjugat
    • 15
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser SETD2 Antikörper ist unkonjugiert
    Applikation
    • 12
    • 11
    • 10
    • 10
    • 6
    • 4
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    Sequenz
    SLCNSEAENI EPSVMKISSN SFMNVHLESK PVICDSRNLT DHSKFACEEY KQSIGSTSSA SVNHFDDLYQ PIGSSGIASS LQSLPPGIKV DSLTLLKCGE NTSPVLDAVL KSKKSSEFLK HAGKETIVEV GSDLPDSGKG FASRENRRNN GLSGKCLQEA QEEGNSILPE RRGRPEISLD ERGEGGHVHT SDDSEVVFSS CDLNLTMEDS DGVTYALKCD SSGHAPEIVS TVHEDYSGSS ESSNDESDSE DTDSDDSSIP RNRLQSVVVV PKNSTLPMEE TSPCSSRSSQ SYRHYSDHWE D
    Kreuzreaktivität
    Human, Maus, Ratte
    Produktmerkmale
    Polyclonal Antibodies
    Immunogen
    Recombinant fusion protein containing a sequence corresponding to amino acids 803-1103 of human SETD2 (NP_054878.5).
    Isotyp
    IgG
  • Applikationshinweise
    WB,1:500 - 1:2000,IF,1:50 - 1:200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Avoid freeze / thaw cycles.
  • Huang, Gu, Li: "H3K36me3-mediated mismatch repair preferentially protects actively transcribed genes from mutation." in: The Journal of biological chemistry, Vol. 293, Issue 20, pp. 7811-7823, (2019) (PubMed).

    Jia, Long, Miron, Yin, Wei, Zhang, Wu: "Setd2 is associated with strontium-induced bone regeneration." in: Acta biomaterialia, Vol. 53, pp. 495-505, (2018) (PubMed).

    Chen, Liu, Liu, Xia, Zhang, Han, Jiang, Wang, Cao: "Methyltransferase SETD2-Mediated Methylation of STAT1 Is Critical for Interferon Antiviral Activity." in: Cell, Vol. 170, Issue 3, pp. 492-506.e14, (2017) (PubMed).

    Zhu, Lei, Ju, Wang, Huang, Yang, Shao, Zhu, Wei, Fu, Li, Wu: "SPOP-containing complex regulates SETD2 stability and H3K36me3-coupled alternative splicing." in: Nucleic acids research, Vol. 45, Issue 1, pp. 92-105, (2017) (PubMed).

  • Target
    SETD2 (SET Domain Containing 2 (SETD2))
    Andere Bezeichnung
    SETD2 (SETD2 Produkte)
    Synonyme
    Kif9 antikoerper, HBP231 antikoerper, HIF-1 antikoerper, HIP-1 antikoerper, HYPB antikoerper, KMT3A antikoerper, SET2 antikoerper, p231HBP antikoerper, SET domain containing 2 antikoerper, Setd2 antikoerper, SETD2 antikoerper
    Hintergrund
    Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein belonging to a class of huntingtin interacting proteins characterized by WW motifs. This protein is a histone methyltransferase that is specific for lysine-36 of histone H3, and methylation of this residue is associated with active chromatin. This protein also contains a novel transcriptional activation domain and has been found associated with hyperphosphorylated RNA polymerase II.,SETD2,HBP231,HIF-1,HIP-1,HSPC069,HYPB,KMT3A,LLS,SET2,p231HBP,Epigenetics & Nuclear Signaling,Chromatin Modifying Enzymes,Methylation,SETD2
    Molekulargewicht
    175 kDa/192 kDa/287 kDa
    Gen-ID
    29072
    UniProt
    Q9BYW2
    Pathways
    Tube Formation
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