TLR7 Antikörper (Toll-Like Receptor 7)

Details for Product anti-TLR7 Antibody No. ABIN165464, Anbieter: Anmelden zum Anzeigen
Antigen
  • TLR7-like
  • RGD1563357
  • toll like receptor 7
  • toll-like receptor 7
  • TLR7
  • Tlr7
Reaktivität
Human
262
139
43
4
4
3
2
2
2
2
1
1
1
1
1
Wirt
Maus
197
83
2
1
Klonalität (Klon)
Monoklonal ()
Konjugat
Dieser TLR7 Antikörper ist unkonjugiert
19
15
12
11
8
6
5
4
4
3
3
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
Applikation
ELISA, Western Blotting (WB)
201
101
90
73
48
47
38
15
13
6
5
5
4
2
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Immunogen Recombinant TLR7, Accession / GI number: NP_057646
Klon 4F4
Isotyp IgG1, kappa
Reinigung The antibody was purified from mouse ascitic fluids by protein-G affinity chromatography
Plasmids, Primers & others Plasmide, Primers & weitere TLR7 products on genomics-online (e.g. as negative or positive controls)
Antigen
Andere Bezeichnung TLR7 (TLR7 Antibody Abstract)
Hintergrund TLR7 is one of toll-like receptors which are type I transmembrane proteins involved in innate immunity by recognizing microbial conserved structures. These proteins are characterized by multiple copies of leucine rich repeats in the extracellular domain and IL-1 receptor motif in the cytoplasmic domain, and act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors. Human TLR7(hTLR7) is predominantly expressed in lung, placenta and spleen and hTLR7,8 genes are located on the sex chromosome X. hTLR7 may play an important role in detecting and combating viral infections.
Pathways TLR Signalweg, Activation of Innate immune Response, Toll-Like Receptors Cascades
Applikations-hinweise Recommended dilution 1:1000
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1mg/ml
Buffer In Phosphate-Buffered Saline (pH7.4) with 0.1% Sodium Azide
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Bilder des Herstellers
Western Blotting (WB) image for anti-Toll-Like Receptor 7 (TLR7) antibody (ABIN165464) anti-Toll-Like Receptor 7 (TLR7) antibody
Immunofluorescence (IF) image for anti-Toll-Like Receptor 7 (TLR7) antibody (ABIN165464) ICC/IF analysis of TLR7 in THP-1 cells line, stained with DAPI (Blue) for nucleus sta...
Allgemeine Veröffentlichungen Crozat, Beutler: "TLR7: A new sensor of viral infection." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 18, pp. 6835-6, 2004 (PubMed).

Lee, Chuang, Redecke, She, Pitha, Carson, Raz, Cottam: "Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 11, pp. 6646-51, 2003 (PubMed).

Muzio, Natoli, Saccani, Levrero, Mantovani: "The human toll signaling pathway: divergence of nuclear factor kappaB and JNK/SAPK activation upstream of tumor necrosis factor receptor-associated factor 6 (TRAF6)." in: The Journal of experimental medicine, Vol. 187, Issue 12, pp. 2097-101, 1998 (PubMed).

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