Cathepsin D Antikörper (CTSD)

Details for Product anti-CTSD Antibody No. ABIN165386, Anbieter: Anmelden zum Anzeigen
Antigen
  • catD
  • fb93e11
  • fj17b09
  • wu:fb93e11
  • wu:fj17b09
  • LOC398557
  • Cathd
  • CatD
  • LOC100136761
  • CTSD
  • DKFZp469J0315
  • DDBDRAFT_0205785
  • DDBDRAFT_0215012
  • DDB_0205785
  • DDB_0215012
  • CLN10
  • CPSD
  • CD
  • cathepsin D
  • cathepsin D S homeolog
  • lysosomal aspartic protease
  • cathepsin D-like
  • ctsd
  • LOC398557
  • ctsd.S
  • CatD
  • LOC5567565
  • LOC100136761
  • CTSD
  • Cathd
  • ctsD
  • catd
  • Ctsd
  • LOC443060
Reaktivität
Human
327
97
66
7
7
5
5
4
4
3
3
3
2
2
2
2
2
1
1
Wirt
Maus
241
122
15
3
Klonalität (Klon)
Monoklonal ()
Konjugat
Dieser Cathepsin D Antikörper ist unkonjugiert
19
15
11
4
4
3
3
3
3
3
3
3
3
3
3
3
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Applikation
Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
315
170
149
93
40
40
33
21
14
13
13
7
5
3
2
2
2
1
1
1
1
Optionen
Hersteller
Anmelden zum Anzeigen
Hersteller Produkt- Nr.
Anmelden zum Anzeigen
Immunogen Recombinant Cathepsin D , Accession / GI number: NP_001900
Klon 4G2
Isotyp Kappa
Reinigung The antibody was purified from mouse ascitic fluids by protein-G affinity chromatography
Plasmids, Primers & others Plasmide, Primers & weitere Cathepsin D products on genomics-online (e.g. as negative or positive controls)
Antigen Cathepsin D (CTSD)
Andere Bezeichnung Cathepsin D (CTSD Antibody Abstract)
Hintergrund The aspartic protease cathepsin D is one of the major proteolytic enzymes in lysosomes. The cathepsin D gene locates on chromosome 11p15.5 and spans approximately 11 kb with nine exons. Initially synthesized as an inactive precursor of pro-cathepsin D, the enzyme is subsequently converted to its active forms by proteolytic processing. Breast cancer cells, unlike normal cells, secrete high levels of pro-cathepsin D
Pathways Peptide Hormone Metabolism
Applikations-hinweise Recommended dilution 1:1000
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1mg/ml
Buffer In Phosphate-Buffered Saline (pH7.4) with 0.1% Sodium Azide
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Bilder des Herstellers
Western Blotting (WB) image for anti-Cathepsin D (CTSD) antibody (ABIN165386) anti-Cathepsin D (CTSD) antibody
Immunohistochemistry (IHC) image for anti-Cathepsin D (CTSD) antibody (ABIN165386) Paraffin embedded sections of human breast lobule tissue were incubated with anti-hum...
Allgemeine Veröffentlichungen Fusek, Vetvicka: "Dual role of cathepsin D: ligand and protease." in: Biomedical papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia, Vol. 149, Issue 1, pp. 43-50, 2005 (PubMed).

Garcia, Platet, Liaudet, Laurent, Derocq, Brouillet, Rochefort: "Biological and clinical significance of cathepsin D in breast cancer metastasis." in: Stem cells (Dayton, Ohio), Vol. 14, Issue 6, pp. 642-50, 1997 (PubMed).

Fujita, Tanaka, Noguchi, Kono, Himeno, Kato: "Isolation and sequencing of a cDNA clone encoding rat liver lysosomal cathepsin D and the structure of three forms of mature enzymes." in: Biochemical and biophysical research communications, Vol. 179, Issue 1, pp. 190-6, 1991 (PubMed).

Tang, Wong: "Evolution in the structure and function of aspartic proteases." in: Journal of cellular biochemistry, Vol. 33, Issue 1, pp. 53-63, 1987 (PubMed).

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