Angiotensin II Antikörper (Ang II) (N-Term)

Details for Product anti-Ang II Antibody No. ABIN1583979, Anbieter: Anmelden zum Anzeigen
Antigen
  • ANHU
  • SERPINA8
  • ANRT
  • Ang
  • AngII
  • PAT
  • AI265500
  • AngI
  • Aogen
  • Serpina8
  • angiotensinogen
  • angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
  • AGT
  • Agt
Epitop
N-Term
2
2
2
Reaktivität
Human, Maus, Ratte (Rattus)
48
6
5
3
Wirt
Kaninchen
41
8
Klonalität
Polyklonal
Konjugat
Dieser Angiotensin II Antikörper ist unkonjugiert
6
2
1
1
1
1
1
1
1
1
1
1
1
1
1
Applikation
Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
18
13
11
10
7
5
4
4
3
2
2
1
1
1
1
1
1
1
1
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Immunogen KLH-conjugated MAP synthetic peptide corresponding to human angiotensinogen II.
Kreuzreaktivität Maus, Ratte (Rattus)
Reinigung Antibody was purified by Protein-A affinity chromatography.
Andere Bezeichnung Angiotensin II (Ang II Antibody Abstract)
Hintergrund

Alternate Names: Ang-II, Ang II, Angiotensin II, Angiotensin-2, AGT, Angiotensinogen, Serpin A8

Description: Angiotensin II is an essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. In response to lowered blood pressure, the enzyme renin cleaves angiotensinogen to produce angiotensin I (angiotensin 1-10). Angiotensin I is a substrate of ACE (angiotensin converting enzyme) that removes a dipeptide to yield the physiologically active peptide angiotensin II (angiotensin 1-8). Angiotensin II acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone. Genetic variations in angiotensin II are a cause of susceptibility to essential hypertension (EHT). Essential hypertension is a condition in which blood pressure is consistently higher than normal with no identifiable cause.

UniProt P01019
Pathways JAK-STAT Signalweg, ACE Inhibitor Pathway, EGFR Signaling Pathway, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Regulation of Lipid Metabolism by PPARalpha, Protein targeting to Nucleus, Feeding Behaviour, Regulation of long-term Neuronal Synaptic Plasticity
Applikations-hinweise E: 1:500-1:1,000, WB: 1:100-1:500, IHC: 1:100-1:500
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/mL
Buffer Each vial contains 0.1 mg IgG in 0.1 mL (1 mg/mL) of PBS pH 7.4, 25 % glycerol, 1 mg/mL BSA with 0.09 % sodium azide.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen Warning: This product contains sodium azide, which has been classified as Xn (Harmful), in European Directive 67/548/EEC in the concentration range of 0.1 - 1.0 %. When disposing of this reagent through lead or copper plumbing, flush with copious volumes of water to prevent azide build-up in drains.
Handhabung Minimize freeze-thaw cycles.
Lagerung -20 °C
Informationen zur Lagerung Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.
Haltbarkeit 12 months
Bilder des Herstellers
Immunohistochemistry (IHC) image for anti-Angiotensin II (Ang II) (N-Term) antibody (ABIN1583979) anti-Angiotensin II (Ang II) (N-Term) antibody
Produkt verwendet in: Wang, Chang, Qian, Tian, Sun: "Angiotensin II induces an increase in MMP-2 expression in idiopathic ascending aortic aneurysm via AT1 receptor and JNK pathway." in: Acta biochimica et biophysica Sinica, Vol. 47, Issue 7, pp. 539-47, 2016 (PubMed).

Guo, Guan, Pan, Sun, Wang, Ji, Huang, Deng, Zhang, Han, Yi, Namaka, Liu, Deng, Li: "Post-Natal Inhibition of NF-κB Activation Prevents Renal Damage Caused by Prenatal LPS Exposure." in: PLoS ONE, Vol. 11, Issue 4, pp. e0153434, 2016 (PubMed).

Wang, Chang, Sun, Qian, Liu, Pei, Guo, Liu: "Angiotensin II Induces an Increase in Matrix Metalloproteinase 2 Expression in Aortic Smooth Muscle Cells of Ascending Thoracic Aortic Aneurysms Through JNK, ERK1/2, and p38 MAPK Activation." in: Journal of cardiovascular pharmacology, Vol. 66, Issue 3, pp. 285-93, 2015 (PubMed).

Matsuura-Hachiya, Arai, Ozeki, Kikuta, Nishiyama: "Angiotensin-converting enzyme inhibitor (enalapril maleate) accelerates recovery of mouse skin from UVB-induced wrinkles." in: Biochemical and biophysical research communications, Vol. 442, Issue 1-2, pp. 38-43, 2014 (PubMed).

Zhang, Caudle, Wheeler, Zhou, Stuart, Yao, Yin: "TGF-β1/Smad2/3/Foxp3 signaling is required for chronic stress-induced immune suppression." in: Journal of neuroimmunology, Vol. 314, pp. 30-41, 1970 (PubMed).

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