ENC1 Antikörper (C-Term)

Produktnummer ABIN1537267

Produktdetails anti-ENC1 Antikörper

Target: ENC1 (Ectodermal-Neural Cortex 1 (With BTB-Like Domain) (ENC1))

Bindungsspezifität: AA 395-423, C-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ENC1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This ENC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 395-423 amino acids from the C-terminal region of human ENC1.

Klon: RB37065

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: ENC1 Antibody (C-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, keep at -20 °C.

Haltbarkeit: 6 months

Details zu ENC1

Target: ENC1 (Ectodermal-Neural Cortex 1 (With BTB-Like Domain) (ENC1))

Andere Bezeichnung: ENC1 (ENC1 Produkte)

Synonyme: ENC1 antikoerper, LOC559101 antikoerper, CCL28 antikoerper, ENC-1 antikoerper, KLHL35 antikoerper, KLHL37 antikoerper, NRPB antikoerper, PIG10 antikoerper, TP53I10 antikoerper, Xencr-3 antikoerper, enc-1 antikoerper, encr-3 antikoerper, Nrpb antikoerper, ectodermal-neural cortex 1 antikoerper, ectodermal-neural cortex 1 (with BTB domain) L homeolog antikoerper, ENC1 antikoerper, enc1 antikoerper, enc1.L antikoerper, Enc1 antikoerper

Hintergrund: DNA damage and/or hyperproliferative signals activate wildtype p53 tumor suppressor protein (TP53, MIM 191170), inducing cell cycle arrest or apoptosis. Mutations that inactivate p53 occur in 50 % of all tumors. Polyak et al. (1997) [PubMed 9305847] used serial analysis of gene expression (SAGE) to evaluate cellular mRNA levels in a colorectal cancer cell line transfected with p53. Of 7,202 transcripts identified, only 14 were expressed at levels more than 10-fold higher in p53-expressing cells than in control cells. Polyak et al. (1997) [PubMed 9305847] termed these genes 'p53-induced genes,' or PIGs, several of which were predicted to encode redox-controlling proteins. They noted that reactive oxygen species (ROS) are potent inducers of apoptosis. Flow cytometric analysis showed that p53 expression induces ROS production, which increases as apoptosis progresses under some conditions. The authors stated that the PIG10 gene, also called ENC1, encodes an actin-binding protein.

Molekulargewicht: 66130

Gen-ID: 8507

NCBI Accession: NP_001243503, NP_001243504, NP_001243505, NP_003624

UniProt: O14682