MTOR Antikörper (Mechanistic Target of Rapamycin (serine/threonine Kinase)) (AA 2415-2464)

Details for Product anti-FRAP1 Antibody No. ABIN1531910, Anbieter: Anmelden zum Anzeigen
Antigen
  • FRAP1
  • FRAP
  • FRAP2
  • RAFT1
  • RAPT1
  • 2610315D21Rik
  • AI327068
  • Frap1
  • flat
  • frap1
  • tor
  • wu:fc22h08
  • mechanistic target of rapamycin kinase
  • mechanistic target of rapamycin
  • mechanistic target of rapamycin (serine/threonine kinase)
  • MTOR
  • Mtor
  • mtor
Epitop
AA 2415-2464, pSer2448
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Reaktivität
Human, Maus, Ratte (Rattus)
407
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16
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Wirt
Kaninchen
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49
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Klonalität
Polyklonal
Konjugat
Dieser MTOR Antikörper ist unkonjugiert
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Applikation
Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
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Optionen
Hersteller
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Hersteller Produkt- Nr.
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Immunogen The antiserum was produced against synthesized peptide derived from human mTOR around the phosphorylation site of Ser2448.
Isotyp IgG
Spezifität

mTOR (Phospho-Ser2448) Antibody detects endogenous levels of mTOR only when phosphorylated at Ser2448.

PhosphorylationH:S2448 M:S2448 R:S2448

Reinigung The antibody was purified from rabbit antiserum by affinity-chromatography using phospho peptide. The antibody against non-phospho peptide was removed by chromatography using corresponding non-phospho peptide.
Reinheit > 95 %
Plasmids, Primers & others Plasmide, Primers & weitere MTOR products on genomics-online (e.g. as negative or positive controls)
Antigen
Andere Bezeichnung mTOR (FRAP1 Antibody Abstract)
Hintergrund

Synonyms: FRAP, FRAP1, FRAP2, RAFT1, Rapamycin target protein, kinase mTOR

NCBI Gene Symbol: MTOR

Molekulargewicht 288 kDa
Gen-ID 2475
OMIM 601231
UniProt P42345
Pathways PI3K-Akt Signalweg, RTK Signalweg, AMPK Signaling, Interferon-gamma Pathway, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Regulation of Actin Filament Polymerization, Regulation of Muscle Cell Differentiation, Regulation of Cell Size, Skeletal Muscle Fiber Development, Regulation of Carbohydrate Metabolic Process, Autophagie, CXCR4-mediated Signaling Events
Applikations-hinweise WB: 1:500~1:1000 IHC: 1:50~1:100 ELISA: 1:40000
Kommentare

Unigene-Number: Hs.338207 (NCBI Gene Symbol: MTOR)

Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/mL
Buffer phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Stable at -20°C for at least 1 year.
Haltbarkeit 12 months
Bilder des Herstellers
Western Blotting (WB) image for anti-Mechanistic Target of Rapamycin (serine/threonine Kinase) (FRAP1) (AA 2415-2464), (pSer2448) antibody (ABIN1531910) Western blot analysis of extracts from HeLa cells treated with EGF 200ng/ml 30', usin...
Immunohistochemistry (IHC) image for anti-Mechanistic Target of Rapamycin (serine/threonine Kinase) (FRAP1) (AA 2415-2464), (pSer2448) antibody (ABIN1531910) Immunohistochemistry analysis of paraffin-embedded human brain, using mTOR (Phospho-S...
Produkt verwendet in: Luo, Yoneda, Ohmori, Sasaki, Shimbo, Eto, Kato, Miyano, Kobayashi, Sasahira, Chihara, Kuniyasu: "Cancer usurps skeletal muscle as an energy repository." in: Cancer research, Vol. 74, Issue 1, pp. 330-40, 2014 (PubMed).

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