STAT5B Antikörper (AA 40-280)

Produktnummer ABIN1513572

Produktdetails anti-STAT5B Antikörper

Target: STAT5B (Signal Transducer and Activator of Transcription 5B (STAT5B))

Bindungsspezifität: AA 40-280

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser STAT5B Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Sequenz: SQAWDSVDLD NPQENIKATQ LLEGLVQELQ KKAEHQVGED GFLLKIKLGH YATQLQNTYD RCPMELVRCI RHILYNEQRL VREANNGSSP AGSLADAMSQ KHLQINQTFE ELRLVTQDTE NELKKLQQTQ EYFIIQYQES LRIQAQFGPL AQLSPQERLS RETALQQKQV SLEAWLQREA QTLQQYRVEL AEKHQKTLQL LRKQQTIILD DELIQWKRRQ QLAGNGGPPE GSLDVLQSWC E

Kreuzreaktivität: Human, Ratte

Produktmerkmale: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 40-280 of human STAT5B (NP_036580.2).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:2000,IF,1:20 - 1:50

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid freeze / thaw cycles

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Referenzen für anti-STAT5B Antikörper (ABIN1513572)

Zheng, Xiong, Wu, Chen, Chen, Fleming, Gao, Bi, Ge: "Quantitative Proteomics Analysis Reveals Novel Insights into Mechanisms of Action of Long Noncoding RNA Hox Transcript Antisense Intergenic RNA (HOTAIR) in HeLa Cells." in: Molecular & cellular proteomics : MCP, Vol. 14, Issue 6, pp. 1447-63, (2015) (PubMed).

Details zu STAT5B

Target: STAT5B (Signal Transducer and Activator of Transcription 5B (STAT5B))

Andere Bezeichnung: STAT5B (STAT5B Produkte)

Synonyme: STAT5 antikoerper, stat5 antikoerper, STAT5A antikoerper, STAT5B antikoerper, signal transducer and activator of transcription 5B antikoerper, signal transducer and activator of transcription 5B S homeolog antikoerper, Signal transducer and activator of transcription 5B antikoerper, STAT5B antikoerper, Stat5b antikoerper, stat5b.S antikoerper, LOC490969 antikoerper, sta5b antikoerper, LOC100566752 antikoerper, LOC100052954 antikoerper

Hintergrund: The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL.,STAT5,STAT5B,Epigenetics & Nuclear Signaling,Transcription Factors,Cancer,Signal Transduction,ErbB-HER Signaling Pathway,Endocrine & Metabolism,Immunology & Inflammation,IL-6 Receptor Signaling Pathway,STAT5B

Molekulargewicht: 89 kDa

Gen-ID: 6777

UniProt: P51692

Pathways: JAK-STAT Signalweg, RTK Signalweg, Response to Growth Hormone Stimulus, C21-Steroid Hormone Metabolic Process, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, CXCR4-mediated Signaling Events, Activated T Cell Proliferation