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RAPGEF3 Antikörper (N-Term)
RAPGEF3
Reaktivität: Human, Maus, Ratte
WB, IHC (p)
Wirt: Kaninchen
Polyclonal
unconjugated
Produktnummer ABIN1450085
Produktdetails anti-RAPGEF3 Antikörper
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Target
Alle RAPGEF3 Antikörper anzeigen
RAPGEF3
(Rap Guanine Nucleotide Exchange Factor (GEF) 3 (RAPGEF3))
Bindungsspezifität
Alle Epitope für RAPGEF3 Antikörper
N-Term
Reaktivität
Alle Reaktivitäten für RAPGEF3 Antikörper
Human, Maus, Ratte
Wirt
Alle Wirte für RAPGEF3 Antikörper
Kaninchen
Klonalität
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Polyklonal
Konjugat
Alle Konjugate für RAPGEF3 Antikörper
Dieser RAPGEF3 Antikörper ist unkonjugiert
Applikation
Alle Applikationen für RAPGEF3 Antikörper
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Kreuzreaktivität (Details)
Species reactivity (tested):Human, Mouse, Rat
Aufreinigung
Affinity chromatography purified via peptide column
Immunogen
18 amino acid synthetic peptide near the amino terminus of human EPAC1
Isotyp
IgG
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Anwendungsinformationen
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Applikationshinweise
Optimal working dilution should be determined by the investigator.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Handhabung
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Konzentration
1.0 mg/mL
Buffer
PBS containing 0.02 % Sodium Azide as preservative
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung
Avoid repeated freezing and thawing.
Lagerung
4 °C/-20 °C
Informationen zur Lagerung
Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Details zu RAPGEF3
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Target
RAPGEF3
(Rap Guanine Nucleotide Exchange Factor (GEF) 3 (RAPGEF3))
Andere Bezeichnung
EPAC1 (RAPGEF3 Produkte )
Synonyme
RAPGEF3 antikoerper, epac antikoerper, si:dkey-27m20.2 antikoerper, CAMP-GEFI antikoerper, EPAC antikoerper, EPAC1 antikoerper, HSU79275 antikoerper, bcm910 antikoerper, 2310016P22Rik antikoerper, 9330170P05Rik antikoerper, Epac antikoerper, Epac1 antikoerper, Rap guanine nucleotide exchange factor 3 antikoerper, Rap guanine nucleotide exchange factor 3 S homeolog antikoerper, Rap guanine nucleotide exchange factor (GEF) 3 antikoerper, RAPGEF3 antikoerper, rapgef3.S antikoerper, rapgef3 antikoerper, Rapgef3 antikoerper
Hintergrund
EPAC1, also known as Rap guanine nuclear exchange factor 3 and cAMPGEF-I, is widely expressed but most prominently in brain, heart, kidney, pancreas, spleen, ovary, thyroid and spinal cord. EPAC1 is a cAMP-binding protein with intrinsic guanine nuclear exchange factor activity that couples cAMP production to the activation of Rap, a GTPase belonging to the Ras family. This activation of Rap influences numerous cellular processes such as integrin-mediated cell adhesion, vascular endothelial barrier formation, and cardiac myocyte gap junction formation. Recently, EPAC1 has been suggested to also be involved in the cAMP-dependent regulation of ion channel formation, intracellular Ca++ signalling, ion transporter activity, and exocytosis.Synonyms: RAPGEF3, Rap guanine nuclear exchange factor 3, bcm910, cAMPGEF-I
Gen-ID
10411
NCBI Accession
NP_659099
Pathways
cAMP Metabolic Process
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