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SPINK7/ECRG2 Antikörper (C-Term)

SPINK7 Reaktivität: Human, Maus, Ratte WB, IHC (p), EIA Wirt: Huhn Polyclonal unconjugated
Produktnummer ABIN1450063
  • Target Alle SPINK7/ECRG2 (SPINK7) Antikörper anzeigen
    SPINK7/ECRG2 (SPINK7) (Serine Peptidase Inhibitor, Kazal Type 7 (SPINK7))
    Bindungsspezifität
    • 15
    • 2
    C-Term
    Reaktivität
    • 18
    • 17
    • 8
    • 3
    Human, Maus, Ratte
    Wirt
    • 25
    • 1
    Huhn
    Klonalität
    • 26
    Polyklonal
    Konjugat
    • 6
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser SPINK7/ECRG2 Antikörper ist unkonjugiert
    Applikation
    • 21
    • 13
    • 13
    • 12
    • 4
    • 3
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
    Kreuzreaktivität (Details)
    Species reactivity (tested):Human, Mouse, Rat.
    Aufreinigung
    Affinity chromatography purified via peptide column
    Immunogen
    16 amino acid synthetic peptide near the carboxy terminus of Human ECRG2
    Top Product
    Discover our top product SPINK7 Primärantikörper
  • Applikationshinweise
    Optimal working dilution should be determined by the investigator.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1.0 mg/mL
    Buffer
    PBS containing 0.02 % Sodium Azide as preservative
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target
    SPINK7/ECRG2 (SPINK7) (Serine Peptidase Inhibitor, Kazal Type 7 (SPINK7))
    Andere Bezeichnung
    ECRG-2 (SPINK7 Produkte)
    Synonyme
    Ecg2 antikoerper, Ecrg2 antikoerper, OM antikoerper, ECG2 antikoerper, ECRG2 antikoerper, EG408198 antikoerper, serine peptidase inhibitor, Kazal type 7 antikoerper, serine peptidase inhibitor, Kazal type 7 (putative) antikoerper, Spink7 antikoerper, SPIK7 antikoerper, SPINK7 antikoerper
    Hintergrund
    The esophageal cancer-susceptibility gene 2 (ECRG2), also known as SPINK7, is a novel tumor suppressor gene identified from the human esophagus. It interacts directly with metallothionein 2A and urokinase-type plasminogen activator (uPA), and downregulates the activity of uPA, leading to reduced cancer cell migration, invasion and metastasis. ECRG2 forms a complex with uPA and its receptor uPAR, modifying the dynamic association of uPAR with beta1 integrins and disrupting the Src/MAP kinase pathway that normally stimulates cell migration and invasion. ECRG2 may thus represent a novel therapeutic target for cancer.Synonyms: ECG2, Esophagus cancer-related gene 2 protein, MGC133105, MGC133106, SPINK7, Serine protease inhibitor Kazal-type 7, UNQ745/PRO1474
    Gen-ID
    84651
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