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TMPRSS6 Antikörper (AA 711-811) (HRP)

TMPRSS6 Reaktivität: Human WB, ELISA, IHC (p), IHC (fro) Wirt: Kaninchen Polyclonal HRP
Produktnummer ABIN1416142
  • Target Alle TMPRSS6 Antikörper anzeigen
    TMPRSS6 (Transmembrane Protease, serine 6 (TMPRSS6))
    Bindungsspezifität
    • 14
    • 8
    • 8
    • 6
    • 5
    • 2
    • 1
    AA 711-811
    Reaktivität
    • 45
    • 8
    • 8
    • 6
    • 6
    • 5
    • 2
    • 2
    • 1
    • 1
    Human
    Wirt
    • 43
    • 2
    Kaninchen
    Klonalität
    • 45
    Polyklonal
    Konjugat
    • 13
    • 5
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser TMPRSS6 Antikörper ist konjugiert mit HRP
    Applikation
    • 39
    • 20
    • 13
    • 13
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Homologie
    Human,Mouse,Rat,Dog,Cow,Chicken
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human Matriptase 2
    Isotyp
    IgG
    Top Product
    Discover our top product TMPRSS6 Primärantikörper
  • Applikationshinweise
    WB 1:300-5000
    IHC-P 1:200-400
    IHC-F 1:100-500
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Handhabung
    Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Haltbarkeit
    12 months
  • Target
    TMPRSS6 (Transmembrane Protease, serine 6 (TMPRSS6))
    Andere Bezeichnung
    Matriptase 2 (TMPRSS6 Produkte)
    Synonyme
    IRIDA antikoerper, 1300008A22Rik antikoerper, transmembrane protease, serine 6 antikoerper, transmembrane serine protease 6 antikoerper, Tmprss6 antikoerper, TMPRSS6 antikoerper
    Hintergrund

    Synonyms: Matriptase-2, Matriptase2, Membrane type serine proteinase 2, MTSP 2, MTSP2, PVAE354, TMPRSS 6, TMPRSS6, TMPS6_HUMAN, TMSP 6, TMSP6, Transmembrane protease serine 6, Type II Membrane Serine Proteinase 6.

    Background: Serine protease which hydrolyzes a range of proteins including type I collagen, fibronectin and fibrinogen. Can also activate urokinase-type plasminogen activator with low efficiency. May play a specialized role in matrix remodeling processes in liver. Required to sense iron deficiency. Overexpression suppresses activation of the HAMP promoter.Involvement in disease:Defects in TMPRSS6 are the cause of iron-refractory iron deficiency anemia (IRIDA), also known as hypochromic microcytic anemia with defect in iron metabolism or hereditary iron-handling disorder or pseudo-iron-deficiency anemia. Key features include congenital hypochromic microcytic anemia, very low mean corpuscular erythrocyte volume, low transferrin saturation, abnormal iron absorption characterized by no hematologic improvement following treatment with oral iron, and abnormal iron utilization characterized by a sluggish, incomplete response to parenteral iron.

    Gen-ID
    164656
    Pathways
    Transition Metal Ion Homeostasis
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