mGluR1 + mGluR5 Antikörper (AA 501-600) (HRP)

Produktnummer ABIN1412552

Produktdetails anti-mGluR1 + mGluR5 Antikörper (HRP)

Target: mGluR1 + mGluR5 (mGluR1/5) (Glutamate Receptor, Metabotropic 5/1 (mGluR1/5))

Bindungsspezifität: AA 501-600

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser mGluR1 + mGluR5 Antikörper ist konjugiert mit HRP

Applikation: Western Blotting (WB), ELISA

Kreuzreaktivität: Maus

Homologie: Human,Rat,Dog,Cow,Sheep,Pig,Horse,Chicken

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human MGLUR1 + MGLUR5

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handhabung: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu mGluR1 + mGluR5

Target: mGluR1 + mGluR5 (mGluR1/5) (Glutamate Receptor, Metabotropic 5/1 (mGluR1/5))

Andere Bezeichnung: MGLUR1 + MGLUR5 (mGluR1/5 Produkte)

Hintergrund:

Synonyms: MGLUR1+MGLUR5, GPRC1A, GPRC1E, GRM1, GRM1A, GRM5, Metabotropic glutamate receptor 1, Metabotropic glutamate receptor 5, mGlu1, mGlu5, MGLUR1, MGLUR1A, MGLUR5, MGLUR5B, GRM1_HUMAN, GRM5_HUMAN.

Background: Glutamate is the main excitatory neurotransmitter in the brain. For many years it had been considered to act only on the ligand-gated receptor channels-termed NMDA, AMPA and kainite receptors that are involved in the fast excitatory synaptic transmission. Recently, glutamate has been shown to regulate enzymes producing second messengers via specific receptors coupled to G-proteins. These receptors are called metabotropic glutamate receptors. In expression systems, Group-I receptors stimulate phospholipase C as revealed by an increase in phosphoinositide turnover and calcium release from internal stores. Group-II and -III receptors are coupled to the inhibition of adenylyl cyclase. The Group-I receptors include Metabotropic Glutamate Receptor 5 and Metabotropic Glutamate Receptor 1a. The Group-II receptors in include mGluR2 and mGluR3.