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SLC12A6 Antikörper (AA 401-500) (Alexa Fluor 555)

SLC12A6 Reaktivität: Human IF (cc), IF (p) Wirt: Kaninchen Polyclonal Alexa Fluor 555
Produktnummer ABIN1394285
  • Target Alle SLC12A6 Antikörper anzeigen
    SLC12A6 (Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 6 (SLC12A6))
    Bindungsspezifität
    • 14
    • 8
    • 8
    • 6
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 401-500
    Reaktivität
    • 45
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 41
    • 2
    • 2
    Kaninchen
    Klonalität
    • 44
    • 1
    Polyklonal
    Konjugat
    • 21
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser SLC12A6 Antikörper ist konjugiert mit Alexa Fluor 555
    Applikation
    • 27
    • 24
    • 20
    • 12
    • 12
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Homologie
    Human,Mouse,Rat,Cow,Sheep,Pig,Rabbit
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human SLC12A6/KCC3
    Isotyp
    IgG
    Top Product
    Discover our top product SLC12A6 Primärantikörper
  • Applikationshinweise
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Haltbarkeit
    12 months
  • Target
    SLC12A6 (Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 6 (SLC12A6))
    Andere Bezeichnung
    SLC12A6/KCC3 (SLC12A6 Produkte)
    Synonyme
    Kcc3 antikoerper, ACCPN antikoerper, KCC3 antikoerper, KCC3A antikoerper, KCC3B antikoerper, 9530023I19Rik antikoerper, gaxp antikoerper, solute carrier family 12, member 6 antikoerper, solute carrier family 12 member 6 antikoerper, Slc12a6 antikoerper, SLC12A6 antikoerper
    Hintergrund

    Synonyms: ACCPN, Furosemide sensitive KCl cotransporter 3, Gaxp, KCC 3, KCC 3A, KCC 3B, KCC3 A, KCC3, KCC3 B, KCC3A, KCC3B, Potassium chloride cotransporter 3, Potassium chloride cotransporter KCC3a S3, SLC12 A6, SLC12A 6, Solute carrier family 12 potassium/chloride transporters, member 6, Solute carrier family 12, member 6, S12A6_HUMAN.

    Background: The four isoforms of potassium/chloride co-transport channels (KCC) belong to a superfamily of cation-chloride co-transporters involved in cell volume maintenance. Nitric oxide (NO) donors activate KCCs, while inhibitors of the cGMP pathway prevent NO donor activation. The ubiquitously expressed KCC1 contains 12 transmembrane domains with both cytoplasmic N and C terminal domains. KCC2 expression is limited to neuronal tissues by a restrictive element similar to the neuronal-restrictive silencing factor. In neurons, KCC2 expression is correlated with an inhibitory response to GABA, while the absence of KCC2 is necessary for an unusual excitatory response to GABA. Alterations of KCC2 expression in the inferior colliculus of rat brain may be related to seizure susceptibility. Conversely, KCC3 is not suspected to play a major role in epilepsy. The two splice variants of KCC3, KCC3a and KCC3b, are predominantly expressed in brain and kidney, respectively, while KCC4 is expressed in muscle, brain, lung, heart and kidney.

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